Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | ADK | P55263 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 5/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5377574 | 0.79 | CSNK1D (0.46) | NISCHPDE3BPDE3AALDH1A1MAP3K8 | |
| SCHEMBL17801023 | 0.76 | LRRK2 (0.52) | MAP3K8MKNK1CHEK1 | |
| SCHEMBL722191 | 0.74 | NISCH (0.78) | NISCHMTORADKPDE3BPDE3A | |
| SCHEMBL17801062 | 0.74 | BTK (0.50) | JAK2CDK2DCLK1PRKD3MAP4K4 | |
| SCHEMBL8253395 | 0.73 | VCP (0.47) | NISCHMTORADKJAK2MKNK1 | |
| SCHEMBL482406 | 0.73 | NISCH (0.64) | NISCHMTORADKPDE3BPDE3A | |
| SCHEMBL17801017 | 0.72 | PDPK1 (0.60) | KDM4EALDH1A1CHEK1PDPK1 | |
| SCHEMBL17801025 | 0.72 | LRRK2 (0.50) | CLK4MKNK1PDPK1 | |
| SCHEMBL862114 | 0.72 | NISCH (0.75) | NISCHMTORADKPDE3BPDE3A | |
| SCHEMBL5914856 | 0.71 | NISCH (0.62) | NISCHMTORADKPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |