Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.45 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.41 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 2/20 | 0.41 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | ROS1 | P08922 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801075 | 0.87 | PDPK1 (0.52) | MAP2K4MAP3K5TTKMAP2K7PLK4 | |
| SCHEMBL17801079 | 0.84 | PDPK1 (0.49) | AAK1CLK2CSNK2A1DYRK1AITK | |
| SCHEMBL17801078 | 0.81 | CSNK1D (0.49) | CSNK1DMAP2K4MAP3K5TTKMAPK1 | |
| SCHEMBL17801071 | 0.79 | MAP3K5 (0.54) | MAP3K5DYRK1A | |
| SCHEMBL17801077 | 0.75 | PARP1 (0.43) | MAP2K4MAP3K5AURKBMAP4K4CLK2 | |
| SCHEMBL8253362 | 0.74 | CSNK1D (0.52) | CSNK1DAAK1MAP2K4MAP3K5NTRK1 | |
| SCHEMBL5377458 | 0.71 | CSNK1D (0.55) | CSNK1DAAK1MAP2K4MAP3K5NTRK1 | |
| SCHEMBL17801093 | 0.69 | CPT1A (0.63) | CSNK1DAAK1 | |
| SCHEMBL17801086 | 0.68 | PDPK1 (0.47) | AAK1CLK2CSNK2A1DYRK1AITK | |
| SCHEMBL1460755 | 0.68 | MAPK1 (0.61) | CSNK1DMAP2K4NTRK1TTKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |