Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.49 |
| ▸ | CLK2 | P49760 | 7/20 | 0.47 |
| ▸ | CLK3 | P49761 | 7/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.47 |
| ▸ | WNT1 | P04628 | 8/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.46 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801086 | 0.85 | PDPK1 (0.47) | PDPK1CLK2CLK3DYRK1AWNT1 | |
| SCHEMBL17801072 | 0.84 | CSNK1D (0.46) | PDPK1CLK2DYRK1AAAK1ITK | |
| SCHEMBL17801078 | 0.82 | CSNK1D (0.49) | — | |
| SCHEMBL17801071 | 0.81 | MAP3K5 (0.54) | DYRK1AWNT1 | |
| SCHEMBL2865036 | 0.79 | PDPK1 (0.65) | PDPK1AAK1ITKCSNK2A1 | |
| SCHEMBL17801075 | 0.79 | PDPK1 (0.52) | PDPK1 | |
| SCHEMBL17801100 | 0.79 | WNT1 (0.44) | PDPK1CLK2CLK3DYRK1AWNT1 | |
| SCHEMBL17801077 | 0.76 | PARP1 (0.43) | CLK2DYRK1A | |
| SCHEMBL5381303 | 0.75 | AAK1 (0.52) | PDPK1CLK2CLK3DYRK1AWNT1 | |
| SCHEMBL5381639 | 0.74 | AAK1 (0.59) | PDPK1CLK2CLK3DYRK1AAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |