Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 17/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 6/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.38 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.38 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.38 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801078 | 0.78 | CSNK1D (0.49) | MAP2K4MAPK1MAPKAPK3MAPK6MAP3K5 | |
| SCHEMBL17801071 | 0.77 | MAP3K5 (0.54) | DYRK1AMAP3K5 | |
| SCHEMBL17801075 | 0.77 | PDPK1 (0.52) | MAP2K4MAP3K5 | |
| SCHEMBL17801079 | 0.76 | PDPK1 (0.49) | CLK2DYRK1A | |
| SCHEMBL17801072 | 0.75 | CSNK1D (0.46) | MAP2K4MAP4K4CLK2DYRK1AAURKB | |
| SCHEMBL17801051 | 0.74 | PARP1 (0.44) | PARP1PARP2MAP2K4MAP4K4CSF1R | |
| SCHEMBL17801050 | 0.69 | MAP2K4 (0.53) | PARP1PARP2MAP2K4PIM1MAPK1 | |
| SCHEMBL17801053 | 0.63 | MAP3K5 (0.55) | DYRK1AMAP3K5 | |
| SCHEMBL27617306 | 0.62 | MAP2K4 (0.49) | MAP2K4MAPK1MAPKAPK2MAPKAPK3MAPK6 | |
| SCHEMBL2955892 | 0.62 | PARP1 (0.54) | PARP1PARP2MAP4K4CSF1RPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |