Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.48 |
| ▸ | TTK | P33981 | 8/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.43 |
| ▸ | GRK6 | P43250 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.37 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801072 | 0.87 | CSNK1D (0.46) | PDPK1MAP3K5TTKPLK4MAP2K4 | |
| SCHEMBL17801078 | 0.81 | CSNK1D (0.49) | MAP3K5TTKLRRK2MAPK8MAP2K4 | |
| SCHEMBL17801079 | 0.79 | PDPK1 (0.49) | PDPK1 | |
| SCHEMBL17801071 | 0.79 | MAP3K5 (0.54) | MAP3K5LRRK2MAPK8 | |
| SCHEMBL17801077 | 0.77 | PARP1 (0.43) | MAP3K5MAP2K4 | |
| SCHEMBL2568971 | 0.70 | TTK (0.58) | PDPK1MAP3K5TTKPLK4LRRK2 | |
| SCHEMBL12813359 | 0.69 | PDPK1 (1.00) | PDPK1MAP3K5TTKPLK4JAK2 | |
| SCHEMBL922900 | 0.67 | JAK2 (0.70) | PDPK1MAP3K5TTKPLK4LRRK2 | |
| SCHEMBL2570707 | 0.67 | MAPK1 (0.57) | PDPK1MAP3K5TTKLRRK2MAP2K4 | |
| SCHEMBL17801050 | 0.66 | MAP2K4 (0.53) | MAP3K5TTKMAPK8MAP2K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |