Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801094 | 0.85 | PLK1 (0.35) | TLR8TLR7RXRARXRBRXRG | |
| SCHEMBL31319478 | 0.76 | PIM1 (0.37) | RXRARXRBRXRGKMT2AMEN1 | |
| SCHEMBL9904375 | 0.75 | CYP4F2 (0.38) | RXRARXRBRXRGMAPTLMNA | |
| SCHEMBL17801066 | 0.75 | HCRTR1 (0.40) | RXRARXRBRXRG | |
| SCHEMBL30182911 | 0.74 | MAPT (0.38) | RXRARXRBRXRGRAB9AKMT2A | |
| SCHEMBL17801065 | 0.73 | ALDH1A1 (0.46) | TLR8TLR7KMT2AMAPTTSHR | |
| SCHEMBL5377785 | 0.73 | ATM (0.36) | RXRARXRBRXRGMAPTLMNA | |
| SCHEMBL4084909 | 0.73 | RXRA (0.36) | RXRARXRBRXRG | |
| SCHEMBL22160453 | 0.72 | CYP4F2 (0.39) | RXRARXRBRXRGLMNAALDH1A1 | |
| SCHEMBL30950223 | 0.72 | CYP4F2 (0.39) | RXRARXRBRXRGRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |