SCHEMBL17802432

SCHEMBL17802432

S=C1CCCN1Cc1ccc(Cl)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.50
ALDH1A1 P00352 1/20 0.50
SIGMAR1 Q99720 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.42
HDAC1 Q13547 3/20 0.42
HDAC6 Q9UBN7 3/20 0.42
HDAC8 Q9BY41 2/20 0.42
HDAC3 O15379 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC10 Q969S8 1/20 0.42
HDAC11 Q96DB2 1/20 0.42
HDAC9 Q9UKV0 1/20 0.42
HDAC5 Q9UQL6 1/20 0.42
NCOR2 Q9Y618 1/20 0.42
ERCC1 P07992 1/20 0.41
ERCC4 Q92889 1/20 0.41
KCNH2 Q12809 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13946682 0.83 SMN1; SMN2 (0.58) ALDH1A1L3MBTL1HDAC1HDAC6SMN1; SMN2
SCHEMBL7961750 0.81 CHRNA7 (0.56) ALDH1A1SMN1; SMN2MEN1KMT2A
SCHEMBL11490206 0.81 L3MBTL1 (0.64) ALDH1A1SIGMAR1L3MBTL1MEN1KMT2A
SCHEMBL10399987 0.79 L3MBTL1 (0.67) KDM4EALDH1A1L3MBTL1ERCC1ERCC4
SCHEMBL7956397 0.78 CHRNA7 (0.56) ALDH1A1SMN1; SMN2MEN1KMT2A
SCHEMBL17479608 0.76 CHRNA7 (0.55) ALDH1A1SMN1; SMN2MEN1KMT2A
SCHEMBL22743960 0.75 GAA (0.54) KDM4EALDH1A1SIGMAR1HDAC1HDAC6
SCHEMBL28896233 0.74 SLC6A4 (0.40) SIGMAR1HDAC1HDAC6SMN1; SMN2HRH3
SCHEMBL29483480 0.74 HDAC1 (0.63) KDM4EALDH1A1L3MBTL1HDAC1HDAC6
SCHEMBL4357989 0.74 HDAC1 (0.63) KDM4EALDH1A1L3MBTL1HDAC1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3227294-A1 1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE Astrazeneca AB (SE) 2017-10-11 EP disclosed
WO-2016087338-A1 1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE ASTRAZENECA AB (SE) 2016-06-09 WO disclosed