Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.36 |
| ▸ | LSS | P48449 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17802432 | 0.74 | KDM4E (0.50) | HRH3SMN1; SMN2SIGMAR1HDAC1HDAC6 | |
| SCHEMBL13946682 | 0.73 | SMN1; SMN2 (0.58) | HRH3SMN1; SMN2POLBHDAC1HDAC6 | |
| SCHEMBL28896063 | 0.71 | KCNN4 (0.42) | SMN1; SMN2POLBTSHR | |
| SCHEMBL28896415 | 0.71 | SIGMAR1 (0.40) | SLC6A4SLC6A2SLC6A3HRH3SMN1; SMN2 | |
| SCHEMBL7961750 | 0.68 | CHRNA7 (0.56) | SMN1; SMN2 | |
| SCHEMBL11490206 | 0.68 | L3MBTL1 (0.64) | HRH3POLBSIGMAR1TSHR | |
| SCHEMBL22743960 | 0.66 | GAA (0.54) | HRH3SMN1; SMN2SIGMAR1HDAC1HDAC6 | |
| SCHEMBL7956397 | 0.65 | CHRNA7 (0.56) | SMN1; SMN2 | |
| SCHEMBL17479608 | 0.64 | CHRNA7 (0.55) | SMN1; SMN2 | |
| SCHEMBL20499449 | 0.63 | SLC6A4 (0.53) | SLC6A4SLC6A2SLC6A3HTR2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403584-B | 2-thio-2, 3-dihydropyrimidine-4-one derivatives, pharmaceutical compositions, preparation methods and applications thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115403584-A | 2-thio-2, 3-dihydropyrimidine-4-one derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-11-29 | — | — | CN | disclosed |