Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KDM1A | O60341 | 1/20 | 0.53 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | PI4KA | P42356 | 1/20 | 0.50 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.50 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29975518 | 1.00 | ALDH1A1 (0.56) | ALDH1A1HTTTDP1CYP1A2CYP2C19 | |
| SCHEMBL11803328 | 0.83 | HTT (0.59) | ALDH1A1HTTTDP1MAPTLMNA | |
| SCHEMBL27212829 | 0.76 | KDM1A (0.58) | ALDH1A1HTTTDP1MAPTLMNA | |
| SCHEMBL11807293 | 0.76 | MAPT (0.65) | ALDH1A1HTTTDP1MAPTLMNA | |
| SCHEMBL5269788 | 0.76 | BCAT2 (0.60) | ALDH1A1HTTTDP1CYP1A2CYP2C19 | |
| SCHEMBL6833209 | 0.75 | EGFR (0.42) | ALDH1A1HTTTDP1CYP1A2CYP2C19 | |
| SCHEMBL6837647 | 0.75 | EGFR (0.42) | EGFRRAB9A | |
| SCHEMBL6213388 | 0.74 | MAPT (0.61) | ALDH1A1HTTTDP1MAPTLMNA | |
| SCHEMBL5136561 | 0.73 | ALDH1A1 (0.58) | ALDH1A1HTTTDP1MAPTLMNA | |
| SCHEMBL5136559 | 0.73 | BCAT2 (0.57) | ALDH1A1HTTTDP1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379749-B1 | UNSYMMETRICAL CYANINE DYES FOR HIGH RESOLUTION NUCLEIC ACID MELTING ANALYSIS | CANON US LIFE SCIENCES INC (US) | 2018-02-14 | — | — | EP | disclosed |
| CN-103874495-B | As the amido quinazoline of inhibitors of kinases | GlaxoSmithKline Intellectual Property Development Ltd. (GB) | 2016-04-20 | — | — | CN | disclosed |
| CN-103874495-A | Amino quinazolines as kinase inhibitors | GLAXO GROUP LTD | 2014-06-18 | — | — | CN | disclosed |
| CN-103298805-A | Quinazoline compounds and methods of use thereof | AMBIT BIOSCIENCES CORP | 2013-09-11 | — | — | CN | disclosed |
| EP-2379749-A1 | UNSYMMETRICAL CYANINE DYES FOR HIGH RESOLUTION NUCLEIC ACID MELTING ANALYSIS | Canon U.S. Life Sciences, Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| US-7943320-B2 | Unsymmetrical cyanine dyes for high resolution nucleic acid melting analysis | CANON U.S. LIFE SCIENCES, INC. (US) | 2011-05-17 | — | — | US | disclosed |
| WO-2010078154-A1 | UNSYMMETRICAL CYANINE DYES FOR HIGH RESOLUTION NUCLEIC ACID MELTING ANALYSIS | CANON U.S. LIFE SCIENCES, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| US-20100167279-A1 | UNSYMMETRICAL CYANINE DYES FOR HIGH RESOLUTION NUCLEIC ACID MELTING ANALYSIS | CANON U.S. LIFE SCIENCES, INC. (US) | 2010-07-01 | — | — | US | disclosed |
| US-20090312322-A1 | Use of Oxindole Derivatives in the Treatment of Dementia Related Diseases, Alzheimer's Disease and Conditions Associated with Glycogen Synthase Kinase-3 | ASTRAZENECA AB (SE) | 2009-12-17 | — | — | US | disclosed |
| WO-2009085879-A2 | C20-C21 SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS | SCHERING CORPORATION (US) | 2009-07-09 | — | — | WO | disclosed |
| US-4855420-A | Cephalosporin derivatives | ICI PHARMA (FR) | 1989-08-08 | — | — | US | disclosed |
| US-4678781-A | BACTERICIDAL ANTIBIOTICS | ICI PHARMA (FR) | 1987-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312322-A1 | Use of Oxindole Derivatives in the Treatment of Dementia Related Diseases, Alzheimer's Disease and Conditions Associated with Glycogen Synthase Kinase-3 | GSK3A, GSK3B, PSEN1 | ALDH1A1 2885/4885HTT 555/4885TDP1 652/4885 |
| US-20100167279-A1 | UNSYMMETRICAL CYANINE DYES FOR HIGH RESOLUTION NUCLEIC ACID MELTING ANALYSIS | POLRMT, DDB1, DDX21 | ALDH1A1 2884/4885HTT 1291/4885TDP1 141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.