Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.37 |
| ▸ | PREP | P48147 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18801701 | 0.82 | SMN1; SMN2 (0.41) | GPBAR1PREPLMNA | |
| SCHEMBL18532583 | 0.79 | GPBAR1 (0.49) | RIPK1GPBAR1LMNA | |
| SCHEMBL17805431 | 0.79 | GPBAR1 (0.49) | RIPK1GPBAR1LMNA | |
| SCHEMBL14960538 | 0.78 | UBE2M (0.36) | ALDH1A1 | |
| SCHEMBL21163658 | 0.78 | UBE2M (0.36) | ALDH1A1 | |
| SCHEMBL18609282 | 0.78 | UBE2M (0.36) | ALDH1A1 | |
| SCHEMBL26006171 | 0.78 | PREP (0.46) | RIPK1GPBAR1PREPLMNA | |
| SCHEMBL2585472 | 0.78 | OPRK1 (0.36) | PREPOPRK1OPRM1OPRD1RAB9A | |
| SCHEMBL2585476 | 0.78 | OPRK1 (0.36) | PREPOPRK1OPRM1OPRD1RAB9A | |
| SCHEMBL2580248 | 0.78 | OPRK1 (0.36) | PREPOPRK1OPRM1OPRD1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2381778-B1 | C5AR ANTAGONISTS | CHEMOCENTRYX INC (US) | 2016-06-08 | — | — | EP | disclosed |