Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18532583 | 0.83 | GPBAR1 (0.49) | GPBAR1LMNACCNCCDK8 | |
| SCHEMBL17805431 | 0.83 | GPBAR1 (0.49) | GPBAR1LMNACCNCCDK8 | |
| SCHEMBL26006171 | 0.82 | PREP (0.46) | GPBAR1PREPLMNACCNCCDK8 | |
| SCHEMBL17805403 | 0.82 | RIPK1 (0.38) | GPBAR1PREPLMNA | |
| SCHEMBL17805452 | 0.82 | GPBAR1 (0.40) | SMN1; SMN2GPBAR1PREP | |
| SCHEMBL24045646 | 0.79 | GPBAR1 (0.42) | GPBAR1CCR5PREPLMNACCNC | |
| SCHEMBL22043704 | 0.79 | GPBAR1 (0.42) | GPBAR1CCR5PREPLMNACCNC | |
| SCHEMBL30103461 | 0.79 | GPBAR1 (0.42) | GPBAR1CCR5PREPLMNACCNC | |
| SCHEMBL18801722 | 0.78 | SMN1; SMN2 (0.39) | SMN1; SMN2HPGDPOLBCCNCCDK8 | |
| SCHEMBL18609682 | 0.78 | RIPK1 (0.46) | GPBAR1PREPLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585064-B1 | C5AR ANTAGONISTS | CHEMOCENTRYX INC (US) | 2017-05-03 | — | — | EP | disclosed |