Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 13/20 | 0.36 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30945197 | 0.88 | AR (0.43) | ARSLC22A12 | |
| SCHEMBL662161 | 0.88 | AR (0.43) | ARSLC22A12 | |
| SCHEMBL21994516 | 0.85 | MAOB (0.36) | MAOBMAOAARSLC1A5SLC22A12 | |
| SCHEMBL15716096 | 0.80 | MAOB (0.38) | MAOBMAOAARSLC1A5CHEK1 | |
| SCHEMBL17157519 | 0.77 | MAOB (0.36) | MAOBMAOAARSLC1A5CHEK1 | |
| SCHEMBL1226983 | 0.76 | AR (0.56) | AR | |
| SCHEMBL18212168 | 0.74 | KIF11 (0.54) | ARSLC22A12 | |
| SCHEMBL1395661 | 0.73 | MAOB (0.61) | MAOBMAOASLC1A5CHEK1 | |
| SCHEMBL30475151 | 0.73 | MAOB (0.61) | MAOBMAOASLC1A5CHEK1 | |
| SCHEMBL80153 | 0.72 | TRPV4 (0.43) | MAOBMAOAARSLC1A5CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197551-B1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME (US) | 2016-12-28 | — | — | EP | disclosed |
| US-8455638-B2 | Soluble guanylate cyclase activators | MERCK SHARP & DOHME CORP. (US) | 2013-06-04 | — | — | US | disclosed |
| US-20110118282-A1 | Soluble Guanylate Cyclase Activators | MERCK SHARP & DOHME LLC | 2011-05-19 | — | — | US | disclosed |
| US-20090209556-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME CORP. | 2009-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118282-A1 | Soluble Guanylate Cyclase Activators | GUCY1B1, GUCY1A2, GUCY1A1 | MAOB 606/4885MAOA 609/4885AR 1646/4885 |
| US-20090209556-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | GUCY1B1, GUCY1A2, GUCY1A1 | MAOB 606/4885MAOA 609/4885AR 1646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.