Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14718132 | 0.76 | CES1 (0.32) | MAPTKMT2AMEN1HPGD | |
| SCHEMBL17070930 | 0.74 | HPGD (0.57) | LMNATP53MAPTCYP1A2CYP3A4 | |
| SCHEMBL7087174 | 0.71 | GABRA1 (0.64) | LMNABRD4 | |
| SCHEMBL64294 | 0.69 | KMT2A (0.48) | LMNATP53MAPTCYP1A2CYP3A4 | |
| SCHEMBL6294237 | 0.66 | KMT2A (0.46) | LMNATP53MAPTCYP1A2CYP3A4 | |
| SCHEMBL14719197 | 0.66 | TP53 (0.47) | LMNATP53MAPTCYP1A2CYP3A4 | |
| Phenindione SCHEMBL33831 | 0.64 | MAPT (1.00) | LMNATP53MAPTCYP1A2CYP3A4 | |
| Phenindione SCHEMBL29388073 | 0.64 | MAPT (1.00) | LMNATP53MAPTCYP1A2CYP3A4 | |
| SCHEMBL7094749 | 0.64 | GABRA1 (0.62) | LMNA | |
| SCHEMBL9952138 | 0.64 | CHEK1 (0.49) | LMNATP53MAPTCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365584-B2 | Thieno [2,3-B] pyridinedione activators of AMPK and therapeutic uses thereof | POXEL (FR) | 2016-06-14 | — | — | US | disclosed |