Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29915854 | 1.00 | CHEK1 (0.49) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL17583585 | 0.90 | GABRP (0.44) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL29915935 | 0.88 | MEN1 (0.52) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL23959070 | 0.86 | MEN1 (0.44) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL28735590 | 0.86 | MEN1 (0.46) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL23959045 | 0.86 | RAB9A (0.46) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL6904077 | 0.84 | CHEK1 (0.65) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL23959055 | 0.84 | RAB9A (0.51) | GAASMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL17583584 | 0.83 | MEN1 (0.45) | CHEK1AURKADAPK3JAK2PRKD3 | |
| Iodide SCHEMBL28598560 | 0.82 | CHEK1 (0.62) | CHEK1AURKADAPK3JAK2PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021212974-A1 | RACEMIC AND CHIRAL 3-(2,3-BUTADIENYL)OXYINDOLINONE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 复旦大学 (CN) | 2021-10-28 | — | — | WO | disclosed |
| CN-108440378-B | Preparation method of iodine-hydrogen peroxide promoted 3-amino-2-indolone derivative at room temperature | 宁波大学 | 2021-03-12 | — | — | CN | disclosed |
| CN-108409630-B | Preparation method of 3-hydroxy-2-indolone derivative in aqueous phase | 宁波大学 | 2021-01-15 | — | — | CN | disclosed |
| CN-108003086-B | Preparation method of 3-amino-2-indolone compound | 宁波大学 | 2020-08-14 | — | — | CN | disclosed |
| CN-107686460-B | Preparation method of 3-substituted-3-hydroxy-2-indolone compound | 宁波大学 | 2020-06-12 | — | — | CN | disclosed |
| CN-108409630-A | preparation method of 3-hydroxy-2-indolone derivative in aqueous phase | 宁波大学 | 2018-08-17 | — | — | CN | disclosed |
| CN-103380126-B | Process for preparing 2- (triazinylcarbonyl) sulfonanilides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-01-20 | — | — | CN | disclosed |
| US-9096551-B2 | Method for producing 2-(triazinylcarbonyl) sulfonanilides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-08-04 | — | — | US | disclosed |
| EP-2655346-B1 | PROCESS FOR THE PREPARATION OF 2-(TRIAZINYLCARBONYL)SULFONANILIDES | BAYER IP GMBH (DE) | 2015-01-21 | — | — | EP | disclosed |
| US-20140024828-A1 | Method for producing 2-(triazinylcarbonyl) sulfonanilides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-01-23 | — | — | US | disclosed |
| EP-2655346-A2 | METHOD FOR PRODUCING 2-(TRIAZINYLCARBONYL) SULFONANILIDES | Bayer Intellectual Property GmbH (DE) | 2013-10-30 | — | — | EP | disclosed |
| CN-103380126-A | Process for preparing 2- (triazinylcarbonyl) sulfonanilides | BAYER IP GMBH | 2013-10-30 | — | — | CN | disclosed |
| WO-2012084857-A2 | METHOD FOR PRODUCING 2-(TRIAZINYLCARBONYL) SULFONANILIDES | BAYER CROPSCIENCE AG (DE) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140024828-A1 | Method for producing 2-(triazinylcarbonyl) sulfonanilides | AOX1, SULT1E1, CBR1 | CHEK1 3766/4885AURKA 1561/4885DAPK3 4426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.