Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cyclobenzaprine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 5/20 | 0.82 |
| ▸ | HTR2C known ✓ | P28335 | 5/20 | 0.82 |
| ▸ | LMNA | P02545 | 6/20 | 0.85 |
| ▸ | PMP22 | Q01453 | 4/20 | 0.85 |
| ▸ | MEN1 | O00255 | 4/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.85 |
| ▸ | APEX1 | P27695 | 1/20 | 0.85 |
| ▸ | HRH1 | P35367 | 8/20 | 0.82 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.82 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.82 |
| ▸ | HTR2B | P41595 | 6/20 | 0.82 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.82 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.82 |
| ▸ | DRD2 | P14416 | 6/20 | 0.82 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.82 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.82 |
| ▸ | DRD3 | P35462 | 6/20 | 0.82 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.82 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.82 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclobenzaprine SCHEMBL17812696 | 0.98 | HRH1 (0.84) | LMNAPMP22MEN1KMT2AAPEX1 | |
| Cyclobenzaprine SCHEMBL4964925 | 0.92 | LMNA (1.00) | LMNAPMP22MEN1KMT2AAPEX1 | |
| Cyclobenzaprine SCHEMBL29350662 | 0.92 | LMNA (1.00) | LMNAPMP22MEN1KMT2AAPEX1 | |
| Cyclobenzaprine SCHEMBL41376 | 0.92 | LMNA (1.00) | LMNAPMP22MEN1KMT2AAPEX1 | |
| Cyclobenzaprine SCHEMBL4606463 | 0.90 | LMNA (0.97) | LMNAPMP22MEN1KMT2AAPEX1 | |
| Cyclobenzaprine SCHEMBL38527 | 0.90 | HRH1 (1.00) | LMNAPMP22MEN1KMT2AAPEX1 | |
| Cyclobenzaprine SCHEMBL7654526 | 0.90 | HRH1 (1.00) | LMNAPMP22MEN1KMT2AAPEX1 | |
| Cyclobenzaprine SCHEMBL29520569 | 0.90 | HRH1 (1.00) | LMNAPMP22MEN1KMT2AAPEX1 | |
| Cyclobenzaprine SCHEMBL1649752 | 0.87 | HRH1 (0.93) | LMNAPMP22MEN1KMT2AAPEX1 | |
| Cyclobenzaprine SCHEMBL29015268 | 0.82 | HRH1 (0.82) | LMNAPMP22MEN1KMT2AAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3311162-B1 | RAPID AND SENSITIVE METHOD OF FORENSIC TOXICOLOGY IN POST-MORTEM SUBJECTS USING ORAL FLUID TESTING | REISINGER AMY J (US) | 2021-12-29 | — | — | EP | disclosed |
| EP-3311162-A1 | RAPID AND SENSITIVE METHOD OF FORENSIC TOXICOLOGY IN POST-MORTEM SUBJECTS USING ORAL FLUID TESTING | Reisinger, Amy J. (US) | 2018-04-25 | — | — | EP | disclosed |
| US-9817006-B2 | Rapid and sensitive method of forensic toxicology in post-mortem subjects using oral fluid testing | REISINGER AMY J (US) | 2017-11-14 | — | — | US | disclosed |
| US-20160370388-A1 | Rapid and Sensitive Method of Forensic Toxicology in Post-Mortem Subjects Using Oral Fluid Testing | REISINGER AMY J (US) | 2016-12-22 | — | — | US | disclosed |
| WO-2016205285-A1 | RAPID AND SENSITIVE METHOD OF FORENSIC TOXICOLOGY IN POST-MORTEM SUBJECTS USING ORAL FLUID TESTING | REISINGER AMY J (US) | 2016-12-22 | — | — | WO | disclosed |
| US-9366685-B1 | Rapid and sensitive method of forensic toxicology in post-mortem subjects using oral fluid testing | REISINGER AMY J (US) | 2016-06-14 | — | — | US | disclosed |