Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | OGA | O60502 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | DRD1 | P21728 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11985799 | 0.79 | L3MBTL1 (0.44) | L3MBTL1PDE3ACYP1A2DYRK1AKEAP1 | |
| SCHEMBL24978834 | 0.78 | KEAP1 (0.36) | L3MBTL1CYP1A2DYRK1AKEAP1RORC | |
| SCHEMBL13676389 | 0.78 | L3MBTL1 (0.41) | L3MBTL1PDE3ACYP1A2DYRK1AKEAP1 | |
| SCHEMBL31212179 | 0.77 | HTR2A (0.36) | PDE3BPDE3ACYP1A2METAP2MCHR1 | |
| SCHEMBL27452784 | 0.74 | L3MBTL1 (0.41) | L3MBTL1PDE3ACYP1A2DYRK1AKEAP1 | |
| SCHEMBL20406365 | 0.74 | L3MBTL1 (0.49) | L3MBTL1PDE3ACYP1A2DYRK1AKEAP1 | |
| SCHEMBL20985971 | 0.74 | DYRK1A (0.44) | L3MBTL1PDE3ACYP1A2DYRK1AKEAP1 | |
| SCHEMBL20517143 | 0.74 | L3MBTL1 (0.41) | L3MBTL1PDE3ACYP1A2DYRK1AKEAP1 | |
| Hydrochloric Acid SCHEMBL31647268 | 0.73 | L3MBTL1 (0.47) | L3MBTL1PDE3ACYP1A2DYRK1AKEAP1 | |
| SCHEMBL22792985 | 0.72 | DYRK1A (0.38) | L3MBTL1PDE3ACYP1A2METAP2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160159809-A1 | HETEROCYCLIC COMPOUNDS AS BIOGENIC AMINE TRANSPORT MODULATORS | SOUTHERN RESEARCH INSTITUTE | 2016-06-09 | — | — | US | disclosed |
| WO-2016090296-A1 | HETEROCYCLIC COMPOUNDS AS BIOGENIC AMINE TRANSPORT MODULATORS | ANANTHAN SUBRAMANIAM (US) | 2016-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160159809-A1 | HETEROCYCLIC COMPOUNDS AS BIOGENIC AMINE TRANSPORT MODULATORS | SLC18A2, SLC6A2, SLC6A3 | L3MBTL1 2745/4885PDE3B 774/4885PDE3A 658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.