Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 14/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.42 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17819216 | 1.00 | ADAMTS5 (0.46) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL17830319 | 0.82 | ADAMTS5 (0.50) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL762368 | 0.82 | ADAMTS5 (0.50) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL762369 | 0.82 | ADAMTS5 (0.50) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL13176600 | 0.81 | ADAMTS5 (0.46) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL17819214 | 0.77 | ADAMTS5 (0.46) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL18123425 | 0.77 | GAA (0.46) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL13803876 | 0.77 | ADAMTS5 (0.46) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL6224351 | 0.75 | GAA (0.41) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL8801472 | 0.74 | ADAMTS5 (0.45) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190023690-A1 | INHIBITORS OF CELLULAR NECROSIS AND RELATED METHODS | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (CN) | 2019-01-24 | — | — | US | disclosed |
| US-9944628-B2 | Inhibitors of cellular necrosis and related methods | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-04-17 | — | — | US | disclosed |
| EP-3229807-A1 | INHIBITORS OF CELLULAR NECROSIS AND RELATED METHODS | President and Fellows of Harvard College (US) | 2017-10-18 | — | — | EP | disclosed |
| US-9499521-B2 | Inhibitors of cellular necrosis and related methods | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-11-22 | — | — | US | disclosed |
| US-20160304498-A1 | INHIBITORS OF CELLULAR NECROSIS AND RELATED METHODS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-10-20 | — | — | US | disclosed |
| WO-2016094846-A1 | INHIBITORS OF CELLULAR NECROSIS AND RELATED METHODS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-06-16 | — | — | WO | disclosed |
| US-20160168128-A1 | INHIBITORS OF CELLULAR NECROSIS AND RELATED METHODS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168128-A1 | INHIBITORS OF CELLULAR NECROSIS AND RELATED METHODS | LITAF, TNF, MMP8 | ADAMTS5 162/4885ADAMTS4 169/4885ADAM17 472/4885 |
| US-20160304498-A1 | INHIBITORS OF CELLULAR NECROSIS AND RELATED METHODS | LITAF, TNF, MMP8 | ADAMTS5 162/4885ADAMTS4 169/4885ADAM17 472/4885 |
| US-20190023690-A1 | INHIBITORS OF CELLULAR NECROSIS AND RELATED METHODS | LITAF, TNF, MMP8 | ADAMTS5 162/4885ADAMTS4 169/4885ADAM17 472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.