⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1476931 | 0.77 | MEN1 (0.34) | — | |
| SCHEMBL6971666 | 0.73 | ALDH1A1 (0.41) | — | |
| SCHEMBL2448790 | 0.72 | MEN1 (0.44) | — | |
| SCHEMBL4650638 | 0.71 | — | — | |
| SCHEMBL3044885 | 0.70 | — | — | |
| SCHEMBL9326124 | 0.70 | — | — | |
| SCHEMBL361683 | 0.70 | — | — | |
| SCHEMBL7344795 | 0.68 | GLA (0.35) | — | |
| SCHEMBL6961881 | 0.67 | KEAP1 (0.32) | — | |
| SCHEMBL3253791 | 0.67 | MEN1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110124653-A1 | ARYL-SULPHONAMIDIC DIMERS AS METALLOPROTEASES INHIBITORS | BRACCO IMAGING S.P.A. (IT) | 2011-05-26 | — | — | US | claimed |
| EP-2323998-A1 | ARYL-SULPHONAMIDIC DIMERS AS METALLOPROTEASES INHIBITORS | Bracco Imaging S.p.A (IT) | 2011-05-25 | — | — | EP | claimed |
| US-20100087505-A1 | Compounds Having Aryl-Sulphonamidic Structure Useful As Metalloproteases Inhibitors | BRACCO IMAGING S.P.A. (IT) | 2010-04-08 | — | — | US | claimed |
| EP-2149568-A1 | ARYL-SULPHONAMIDIC DIMERS AS METALLOPROTEASES INHIBITORS | Bracco Imaging S.p.A (IT) | 2010-02-03 | — | — | EP | claimed |
| WO-2010010080-A1 | ARYL-SULPHONAMIDIC DIMERS AS METALLOPROTEASES INHIBITORS | BRACCO IMAGING SPA (IT) | 2010-01-28 | — | — | WO | claimed |
| US-9480758-B2 | Diagnostic agents selective against metalloproteases | BRACCO IMAGING S.P.A. (IT) | 2016-11-01 | — | — | US | disclosed |
| US-8329751-B2 | Compounds having aryl-sulphonamidic structure useful as metalloproteases inhibitors | BRACCO IMAGING S.P.A. (IT) | 2012-12-11 | — | — | US | disclosed |
| US-20110124653-A1 | ARYL-SULPHONAMIDIC DIMERS AS METALLOPROTEASES INHIBITORS | BRACCO IMAGING S.P.A. (IT) | 2011-05-26 | — | — | US | disclosed |
| EP-2323998-A1 | ARYL-SULPHONAMIDIC DIMERS AS METALLOPROTEASES INHIBITORS | Bracco Imaging S.p.A (IT) | 2011-05-25 | — | — | EP | disclosed |
| US-20110117015-A1 | Diagnostic Agents Selective Against Metalloproteases | BRACCO IMAGING S.P.A. (IT) | 2011-05-19 | — | — | US | disclosed |
| US-20100087505-A1 | Compounds Having Aryl-Sulphonamidic Structure Useful As Metalloproteases Inhibitors | BRACCO IMAGING S.P.A. (IT) | 2010-04-08 | — | — | US | disclosed |
| EP-2149568-A1 | ARYL-SULPHONAMIDIC DIMERS AS METALLOPROTEASES INHIBITORS | Bracco Imaging S.p.A (IT) | 2010-02-03 | — | — | EP | disclosed |
| WO-2010010080-A1 | ARYL-SULPHONAMIDIC DIMERS AS METALLOPROTEASES INHIBITORS | BRACCO IMAGING SPA (IT) | 2010-01-28 | — | — | WO | disclosed |
| EP-2147684-A1 | Diagnostic Agents Selective Against Metalloproteases | Bracco Imaging S.p.A (IT) | 2010-01-27 | — | — | EP | disclosed |