Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Quinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.94 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | CASP1 | P29466 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL10711398 | 1.00 | ALDH1A1 (0.94) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL27894663 | 1.00 | ALDH1A1 (0.94) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL27560090 | 1.00 | ALDH1A1 (0.94) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL28089949 | 0.97 | ALDH1A1 (0.90) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL2774 | 0.97 | ALDH1A1 (1.00) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL29822171 | 0.97 | ALDH1A1 (1.00) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL1270969 | 0.97 | ALDH1A1 (1.00) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL29349552 | 0.97 | ALDH1A1 (1.00) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL32661377 | 0.97 | ALDH1A1 (1.00) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL23202414 | 0.94 | ALDH1A1 (0.94) | ALDH1A1NPC1POLBRAB9ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 151 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118084934-A | Fluorescent probe for detecting NADH, preparation method and biological application thereof | 天津理工大学 | 2024-05-28 | — | — | CN | claimed |
| CN-113072553-B | Preparation method and application of dehydrobufotenine | 河北工业大学 | 2022-02-25 | — | — | CN | claimed |
| CN-106140597-B | A kind of powder filter device and its method of work with automatic feed back function | 徐州工程学院 | 2018-04-10 | — | — | CN | claimed |
| CN-122079883-A | Long alkyl chain lysosome fluorescent probe and method, composition, preparation, kit and application thereof | — | 2026-05-26 | — | — | CN | disclosed |
| CN-121574125-A | Selenium-containing aggregation-induced emission organic small molecular compound and application thereof in radioactive photodynamic therapy | 大连理工大学 | 2026-02-27 | — | — | CN | disclosed |
| CN-119954785-B | Viscosity and SO2Double-response fluorescent probe and preparation method and application thereof | 天津理工大学 | 2025-11-21 | — | — | CN | disclosed |
| CN-119954785-A | Viscosity and SO2Double-response fluorescent probe and preparation method and application thereof | 天津理工大学 | 2025-05-09 | — | — | CN | disclosed |
| CN-119403778-A | Process for producing fluorinated organic compound | 大金工业株式会社 | 2025-02-07 | — | — | CN | disclosed |
| US-12173026-B2 | PRMT5 inhibitors | MERCK SHARP & DOHME LLC (US) | 2024-12-24 | — | — | US | disclosed |
| CN-118084934-A | Fluorescent probe for detecting NADH, preparation method and biological application thereof | 天津理工大学 | 2024-05-28 | — | — | CN | disclosed |
| CN-118047754-A | Small molecular fluorescent probe for directly and nondestructively staining and fixing mitochondria in cells and tissues and application thereof | 山东大学 | 2024-05-17 | — | — | CN | disclosed |
| US-5656449-A | STAINING NUCLEIC ACIDS | MOLECULAR PROBES, INC. (US) | 1997-08-12 | — | — | US | disclosed |
| EP-0634640-A1 | Method of counting reticulocytes | OMRON CORPORATION (JP) | 1995-01-18 | — | — | EP | disclosed |
| US-5254478-A | Reducing power required | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 1993-10-19 | — | — | US | disclosed |
| US-5232930-A | Antiinflammatory antiallergen | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-03 | — | — | US | disclosed |
| CN-1073177-A | Novel cephalosporins containing a substituted benzyloxyimino radical in position 7, process for their preparation and their use as medicaments | ROUSSEL UCLAF (FR) | 1993-06-16 | — | — | CN | disclosed |
| EP-0500205-A1 | Benzodioxole derivatives | ZENECA LIMITED (GB) | 1992-08-26 | — | — | EP | disclosed |
| US-RE33223-E | ANTISTATIC FOILS, MOLDINGS, COATINGS | BAYER AKTIENGESELLSCHAFT (DE) | 1990-05-29 | — | — | US | disclosed |
| EP-0260642-A2 | Thiazolo [f]-fused hexahydroquinoline derivatives as dopaminergic agents | WARNER-LAMBERT COMPANY (US) | 1988-03-23 | — | — | EP | disclosed |
| US-4568485-A | TETRACYANOQUINDIMETHANE STABILIZED WITH METAL COMPOUND | BAYER AKTIENGESELLSCHAFT (DE) | 1986-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12173026-B2 | PRMT5 inhibitors | PRMT5, PRMT1, PRMT3 | ALDH1A1 1380/4885NPC1 3442/4885POLB 1842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.