Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMD14 | O00487 | 2/20 | 0.93 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.93 |
| ▸ | MMP2 | P08253 | 2/20 | 0.93 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.93 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.93 |
| ▸ | RAD52 | P43351 | 1/20 | 0.75 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.55 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8362466 | 1.00 | PSMD14 (0.93) | PSMD14PLA2G1BMMP2ATG4BHSP90AA1 | |
| Hydrochloric Acid SCHEMBL10482719 | 1.00 | PSMD14 (0.93) | PSMD14PLA2G1BMMP2ATG4BHSP90AA1 | |
| Hydrochloric Acid SCHEMBL2185310 | 1.00 | PSMD14 (0.93) | PSMD14PLA2G1BMMP2ATG4BHSP90AA1 | |
| SCHEMBL1054173 | 0.98 | PSMD14 (0.96) | PSMD14PLA2G1BMMP2ATG4BHSP90AA1 | |
| SCHEMBL10580148 | 0.98 | PSMD14 (0.96) | PSMD14PLA2G1BMMP2ATG4BHSP90AA1 | |
| Fluoride Ion SCHEMBL9805580 | 0.96 | PSMD14 (0.93) | PSMD14PLA2G1BMMP2ATG4BHSP90AA1 | |
| Hydrochloric Acid SCHEMBL9813245 | 0.95 | PLA2G1B (0.84) | PSMD14PLA2G1BMMP2ATG4BHSP90AA1 | |
| Phosphoric Acid SCHEMBL10482506 | 0.92 | PSMD14 (0.84) | PSMD14PLA2G1BMMP2ATG4BHSP90AA1 | |
| Phosphoric Acid SCHEMBL10482503 | 0.92 | PSMD14 (0.84) | PSMD14PLA2G1BMMP2ATG4BHSP90AA1 | |
| SCHEMBL11077707 | 0.90 | PSMD14 (0.82) | PSMD14PLA2G1BMMP2ATG4BHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2371348-B9 | Oral care composiion | JOHNSON & JOHNSON CONSUMER INC (US) | 2019-11-06 | — | — | EP | disclosed |
| EP-2371347-B1 | Oral care compositions | JOHNSON & JOHNSON CONSUMER INC (US) | 2019-06-12 | — | — | EP | disclosed |
| US-10272022-B2 | Oral care compositions | JOHNSON & JOHNSON CONSUMER INC. (US) | 2019-04-30 | — | — | US | disclosed |
| EP-2371348-B1 | Oral care composiion | JOHNSON & JOHNSON CONSUMER INC (US) | 2019-04-24 | — | — | EP | disclosed |
| EP-2389075-B1 | SUSTAINED RELEASE OF NUTRIENTS IN VIVO | NEW WORLD PHARMACEUTICALS LLC (US) | 2017-11-15 | — | — | EP | disclosed |
| US-20170202789-A1 | METHODS AND RELATED COMPOSITIONS FOR IMPROVED DRUG BIOAVAILABILITY AND DISEASE TREATMENT | NEW WORLD PHARMACEUTICALS, LLC (US) | 2017-07-20 | — | — | US | disclosed |
| US-20170196784-A1 | ORAL CARE COMPOSITIONS | KENVUE BRANDS LLC | 2017-07-13 | — | — | US | disclosed |
| US-9636284-B2 | Oral care compositions | JOHNSON & JOHNSON CONSUMER INC. (US) | 2017-05-02 | — | — | US | disclosed |
| US-9554586-B2 | Sustained release of nutrients in vivo | NEW WORLD PHARMACEUTICALS, LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9538775-B2 | Sustained release of nutrients in vivo | NEW WORLD PHARMACEUTICALS, LLC (US) | 2017-01-10 | — | — | US | disclosed |
| EP-0489037-B1 | ANTI-PLAQUE TOOTHPASTE | HENKEL KGAA (DE) | 1995-08-02 | — | — | EP | disclosed |
| EP-0613365-B1 | HAIR-TINTING AGENTS | HENKEL KGAA (DE) | 1995-08-02 | — | — | EP | disclosed |
| EP-0530229-B1 | OXIDATION COLORANTS FOR KERATIN FIBRES | HENKEL KGAA (DE) | 1995-06-28 | — | — | EP | disclosed |
| EP-0655905-A1 | ALKYL GLYCOSIDES IN DYEING AGENTS. | HENKEL KGAA (DE) | 1995-06-07 | — | — | EP | disclosed |
| WO-1994004124-A1 | ALKYL GLYCOSIDES IN DYEING AGENTS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1994-03-03 | — | — | WO | disclosed |
| US-5182101-A | Biguanides, Cationic Surfactants | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1993-01-26 | — | — | US | disclosed |
| EP-0489037-A1 | ANTI-PLAQUE TOOTHPASTE. | HENKEL KGAA (DE) | 1992-06-10 | — | — | EP | disclosed |
| EP-0150374-B1 | MOUTH AND TOOTH CARE COMPOSITIONS | Henkel Kommanditgesellschaft auf Aktien (DE) | 1991-04-10 | — | — | EP | disclosed |
| WO-1991002511-A1 | ANTI-PLAQUE TOOTHPASTE | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1991-03-07 | — | — | WO | disclosed |
| US-4820507-A | PLAQUE INHIBITORS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1989-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10272022-B2 | Oral care compositions | OSTC, CTRC, WASHC5 | PSMD14 1214/4885PLA2G1B 1751/4885MMP2 3862/4885 |
| US-20170196784-A1 | ORAL CARE COMPOSITIONS | OSTC, CTRC, WASHC5 | PSMD14 1214/4885PLA2G1B 1751/4885MMP2 3862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.