Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | XBP1 | P17861 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MPI | P34949 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19962274 | 1.00 | ALDH1A1 (0.48) | ALDH1A1CA1CA2CA4CA5A | |
| Hydrochloric Acid SCHEMBL17823608 | 0.98 | ALDH1A1 (0.47) | ALDH1A1CA1CA2CA4CA5A | |
| Hydrochloric Acid SCHEMBL28484958 | 0.98 | ALDH1A1 (0.47) | ALDH1A1CA1CA2CA4CA5A | |
| SCHEMBL2622445 | 0.83 | ALDH1A1 (0.46) | ALDH1A1CA1CA2CA4CA5A | |
| SCHEMBL22966529 | 0.81 | CA1 (0.39) | CA1CA2CA4CA5ACA5B | |
| SCHEMBL11494298 | 0.72 | P2RX3 (0.40) | ALDH1A1CA1CA2CA4CA5A | |
| SCHEMBL31339479 | 0.71 | ALDH1A1 (0.65) | ALDH1A1CA1CA2CA4CA5A | |
| SCHEMBL7805145 | 0.71 | ALDH1A1 (0.43) | ALDH1A1CA1CA2CA4CA5A | |
| SCHEMBL17824117 | 0.70 | P2RX3 (0.42) | ALDH1A1LMNAHTTNPC1RAB9A | |
| SCHEMBL24073941 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230053411-A1 | 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2023-02-23 | — | — | US | disclosed |
| CN-110256418-B | 1, 3-thiazol-2-yl substituted benzamides | 拜耳公司 | 2023-01-20 | — | — | CN | disclosed |
| EP-3587417-B9 | 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES | BAYER AG (DE) | 2022-03-30 | — | — | EP | disclosed |
| EP-3587417-B1 | 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES | BAYER AG (DE) | 2022-01-05 | — | — | EP | disclosed |
| US-11142523-B2 | 1,3-thiazol-2-yl substituted benzamides | BAYER AKTIENGESELLSCHAFT (DE) | 2021-10-12 | — | — | US | disclosed |
| EP-3230281-B1 | 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES | BAYER AG (DE) | 2021-05-26 | — | — | EP | disclosed |
| CN-107207507-B | 1, 3-thiazol-2-yl substituted benzamides | 拜耳公司 | 2020-11-06 | — | — | CN | disclosed |
| US-20200131169-A1 | 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2020-04-30 | — | — | US | disclosed |
| US-10472354-B2 | 1,3-thiazol-2-yl substituted benzamides | BAYER AKTIENGESELLSCHAFT (DE) | 2019-11-12 | — | — | US | disclosed |
| US-20190185466-A1 | 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2019-06-20 | — | — | US | disclosed |
| US-10202369-B2 | 1,3-thiazol-2-yl substituted benzamides | BAYER AKTIENGESELLSCHAFT (DE) | 2019-02-12 | — | — | US | disclosed |
| US-10183937-B2 | 1,3-thiazol-2-yl substituted benzamides | BAYER AKTIENGESELLSCHAFT (DE) | 2019-01-22 | — | — | US | disclosed |
| US-10174016-B2 | 1,3-thiazol-2-yl substituted benzamides | BEYER AKTIENGESELLSCHAFT (DE) | 2019-01-08 | — | — | US | disclosed |
| US-20180118731-A1 | 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | US | disclosed |
| US-20180093980-A1 | 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES | EVOTEC AG (DE) | 2018-04-05 | — | — | US | disclosed |
| US-20180072713-A1 | 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES | EVOTEC AG (DE) | 2018-03-15 | — | — | US | disclosed |
| EP-3230281-A1 | 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES | Bayer Aktiengesellschaft (DE) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016091776-A1 | 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES | EVOTEC AG (DE) | 2016-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180093980-A1 | 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES | NAT1, HNMT, PMP22 | ALDH1A1 71/4885CA1 1570/4885CA2 1375/4885 |
| US-20230053411-A1 | 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES | NAT1, HNMT, PMP22 | ALDH1A1 71/4885CA1 1570/4885CA2 1375/4885 |
| US-20180118731-A1 | 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES | NAT1, HNMT, PMP22 | ALDH1A1 71/4885CA1 1570/4885CA2 1375/4885 |
| US-20190185466-A1 | 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES | NAT1, HNMT, PMP22 | ALDH1A1 71/4885CA1 1570/4885CA2 1375/4885 |
| US-10202369-B2 | 1,3-thiazol-2-yl substituted benzamides | NAT1, HNMT, PMP22 | ALDH1A1 71/4885CA1 1570/4885CA2 1375/4885 |
| US-10472354-B2 | 1,3-thiazol-2-yl substituted benzamides | NAT1, HNMT, PMP22 | ALDH1A1 71/4885CA1 1570/4885CA2 1375/4885 |
| US-10174016-B2 | 1,3-thiazol-2-yl substituted benzamides | NAT1, HNMT, PMP22 | ALDH1A1 71/4885CA1 1570/4885CA2 1375/4885 |
| US-10183937-B2 | 1,3-thiazol-2-yl substituted benzamides | NAT1, HNMT, PMP22 | ALDH1A1 71/4885CA1 1570/4885CA2 1375/4885 |
| US-11142523-B2 | 1,3-thiazol-2-yl substituted benzamides | NAT1, HNMT, PMP22 | ALDH1A1 71/4885CA1 1570/4885CA2 1375/4885 |
| US-20180072713-A1 | 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES | NAT1, HNMT, PMP22 | ALDH1A1 71/4885CA1 1570/4885CA2 1375/4885 |
| US-20200131169-A1 | 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES | NAT1, HNMT, PMP22 | ALDH1A1 71/4885CA1 1570/4885CA2 1375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.