SCHEMBL17824488

SCHEMBL17824488

CCSc1cc2cnccc2cc1C(=O)O

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KDM4C Q9H3R0 8/20 0.40
KDM6B O15054 4/20 0.40
HSD17B10 Q99714 1/20 0.40
HASPIN Q8TF76 2/20 0.40
ALDH1A1 P00352 2/20 0.39
MRGPRX4 Q96LA9 1/20 0.38
KDM4E B2RXH2 2/20 0.38
MEN1 O00255 1/20 0.38
KDM4A O75164 1/20 0.38
MAPT P10636 1/20 0.38
THRB P10828 1/20 0.38
KMT2A Q03164 1/20 0.38
KDM4D Q6B0I6 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
IMPDH2 P12268 2/20 0.36
AR P10275 1/20 0.36
PRMT3 O60678 2/20 0.35
HTT P42858 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18050184 0.87 HSD17B10 (0.40) KDM4CHSD17B10HASPINALDH1A1MRGPRX4
SCHEMBL17824524 0.85 ALDH1A1 (0.44) HSD17B10HASPINALDH1A1KDM4EL3MBTL1
SCHEMBL17824532 0.82 HPGD (0.49) HSD17B10ALDH1A1KDM4EMAPTL3MBTL1
SCHEMBL26667218 0.79 KDM4C (0.52) KDM4CKDM6BHASPINALDH1A1MRGPRX4
SCHEMBL1023957 0.79 KDM4C (0.50) KDM4CKDM6BHSD17B10ALDH1A1KDM4E
SCHEMBL16611699 0.79 HSD17B10 (0.49) KDM4CKDM6BHSD17B10ALDH1A1KDM4E
Hydrochloric Acid SCHEMBL16612069 0.77 HSD17B10 (0.48) KDM4CKDM6BHSD17B10ALDH1A1KDM4E
SCHEMBL19439384 0.77 ALDH1A1 (0.43) HSD17B10ALDH1A1KDM4EMEN1KMT2A
SCHEMBL28763682 0.72 ALDH1A1 (0.51) KDM4CKDM6BHASPINALDH1A1MRGPRX4
SCHEMBL20424030 0.71 KDM4C (0.43) KDM4CKDM6BHSD17B10HASPINALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111646989-A Pesticidally active tetracyclic derivatives with sulfur-containing substituents 先正达参股股份有限公司 2020-09-11 CN disclosed
CN-107428751-B Pesticidally active tetracyclic derivatives with sulfur-containing substituents 先正达参股股份有限公司 2020-06-30 CN disclosed
CN-107001364-B Pesticidally active tetracyclic derivatives with sulfur-containing substituents 先正达参股股份有限公司 2020-06-16 CN disclosed
EP-3230284-B1 PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATIONS AG (CH) 2020-04-15 EP disclosed
EP-3230284-B1 PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATIONS AG (CH) 2020-04-15 EP disclosed
US-10323031-B2 Pesticidally active tetracyclic derivatives with sulfur containing substituents SYNGENTA PARTICIPATIONS AG (CH) 2019-06-18 US disclosed
US-10323031-B2 Pesticidally active tetracyclic derivatives with sulfur containing substituents SYNGENTA PARTICIPATIONS AG (CH) 2019-06-18 US disclosed
US-10308650-B2 Pesticidally active tetracyclic derivatives with sulfur containing substituents SYNGENTA PARTICIPATIONS AG (CH) 2019-06-04 US disclosed
US-10308650-B2 Pesticidally active tetracyclic derivatives with sulfur containing substituents SYNGENTA PARTICIPATIONS AG (CH) 2019-06-04 US disclosed
EP-3268365-B1 PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATIONS AG (CH) 2019-02-06 EP disclosed
US-20170349581-A1 PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATION AG (CH) 2017-12-07 US disclosed
US-20170349581-A1 PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATION AG (CH) 2017-12-07 US disclosed
US-20170349581-A1 PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATION AG (CH) 2017-12-07 US disclosed
CN-107428751-A Pesticidally active tetracyclic derivatives with sulfur-containing substituents 先正达参股股份有限公司 2017-12-01 CN disclosed
EP-3230284-A1 PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS Syngenta Participations AG (CH) 2017-10-18 EP disclosed
CN-107001364-A The active tetracyclic of harmful organism is killed with sulfur-bearing substituent 先正达参股股份有限公司 2017-08-01 CN disclosed
WO-2016142326-A1 PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATIONS AG (CH) 2016-09-15 WO disclosed
WO-2016142326-A1 PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATIONS AG (CH) 2016-09-15 WO disclosed
WO-2016091731-A1 PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATIONS AG (CH) 2016-06-16 WO disclosed
WO-2016091731-A1 PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATIONS AG (CH) 2016-06-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10308650-B2 Pesticidally active tetracyclic derivatives with sulfur containing substituents DDT, TST, ACHE KDM4C 2768/4885KDM6B 3773/4885HSD17B10 2547/4885
US-20170349581-A1 PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS DDT, TST, ACHE KDM4C 2768/4885KDM6B 3773/4885HSD17B10 2547/4885
US-10323031-B2 Pesticidally active tetracyclic derivatives with sulfur containing substituents DDT, TST, GSTM1 KDM4C 2909/4885KDM6B 3876/4885HSD17B10 2739/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.