Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10698904 | 0.76 | ALDH1A1 (0.43) | F2PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL14509008 | 0.76 | ALDH1A1 (0.50) | LMNAL3MBTL1 | |
| SCHEMBL28174372 | 0.76 | LMNA (0.59) | LMNA | |
| SCHEMBL28850126 | 0.70 | EGFR (0.49) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL17824589 | 0.68 | FYN (0.33) | — | |
| SCHEMBL30375789 | 0.67 | NAMPT (0.40) | — | |
| SCHEMBL14629169 | 0.63 | LMNA (0.71) | LMNA | |
| SCHEMBL17845255 | 0.62 | PRKCI (0.49) | L3MBTL1 | |
| SCHEMBL17787430 | 0.61 | F2 (0.57) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL663730 | 0.61 | CYP2C19 (0.59) | F2PRSS1PRSS2PRSS3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230273-A1 | 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG | Cancer Research Technology Ltd (GB) | 2017-10-18 | — | — | EP | disclosed |
| CN-107207467-A | 2, 4-dioxo-quinazoline-6-sulfonamide derivatives as inhibitors of PARG | 癌症研究科技有限公司 | 2017-09-26 | — | — | CN | disclosed |
| WO-2016092326-A1 | 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-06-16 | — | — | WO | disclosed |