Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 13/20 | 0.48 |
| ▸ | CA1 | P00915 | 11/20 | 0.48 |
| ▸ | CA9 | Q16790 | 9/20 | 0.48 |
| ▸ | CA12 | O43570 | 9/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 7/20 | 0.48 |
| ▸ | CA7 | P43166 | 6/20 | 0.48 |
| ▸ | CA4 | P22748 | 6/20 | 0.48 |
| ▸ | CA6 | P23280 | 5/20 | 0.48 |
| ▸ | CA5A | P35218 | 5/20 | 0.48 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9839080 | 0.82 | LMNA (0.82) | LMNACA2CA1CA9CA12 | |
| SCHEMBL14509008 | 0.79 | ALDH1A1 (0.50) | LMNACA2CA1CA12CA14 | |
| SCHEMBL10698904 | 0.79 | ALDH1A1 (0.43) | LMNAMEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL566973 | 0.79 | LMNA (0.58) | LMNACA2CA1CA9CA12 | |
| SCHEMBL31203257 | 0.79 | LMNA (0.58) | LMNACA2CA1CA9CA12 | |
| SCHEMBL8550093 | 0.79 | LMNA (0.58) | LMNACA2CA1CA9CA12 | |
| Hydrochloric Acid SCHEMBL22129912 | 0.77 | LMNA (0.56) | LMNACA2CA1CA9CA12 | |
| SCHEMBL17824873 | 0.76 | F2 (0.39) | LMNA | |
| SCHEMBL193716 | 0.74 | LMNA (1.00) | LMNACA2CA1CA9CA12 | |
| SCHEMBL1805612 | 0.72 | LMNA (0.67) | LMNACA2CA1CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107207467-A | 2, 4-dioxo-quinazoline-6-sulfonamide derivatives as inhibitors of PARG | 癌症研究科技有限公司 | 2017-09-26 | — | — | CN | disclosed |