Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.63 |
| ▸ | F2 | P00734 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.51 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 3/20 | 0.48 |
| ▸ | MMP1 | P03956 | 2/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | MMP8 | P22894 | 2/20 | 0.48 |
| ▸ | MMP13 | P45452 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23877964 | 0.87 | ALDH1A1 (0.67) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL25252374 | 0.85 | ALDH1A1 (0.52) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL17825498 | 0.84 | STS (0.58) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL30498701 | 0.84 | ALDH1A1 (0.56) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL23348324 | 0.78 | STS (0.57) | ALDH1A1MMP9MMP1MMP2MMP8 | |
| SCHEMBL23211919 | 0.78 | ALDH1A1 (0.51) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL21381623 | 0.78 | ALDH1A1 (0.51) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL25254415 | 0.77 | ALDH1A1 (0.53) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL17785708 | 0.76 | ALDH1A1 (0.71) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL21815402 | 0.75 | ALDH1A1 (0.57) | ALDH1A1F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230276-A1 | GLP-1 RECEPTOR MODULATORS | Celgene International II Sarl (CH) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016094729-A1 | GLP-1 RECEPTOR MODULATORS | CELGENE INTERNATIONAL II SARL (CH) | 2016-06-16 | — | — | WO | disclosed |