SCHEMBL17825498

SCHEMBL17825498

COc1ccc(S(=O)(=O)NN=C2CN(C(=O)OC(C)(C)C)C2)cc1

nearest known ligand 0.58

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
STS P08842 4/20 0.58
ALDH1A1 P00352 4/20 0.56
MMP1 P03956 7/20 0.51
MMP9 P14780 6/20 0.51
MMP13 P45452 6/20 0.51
MMP3 P08254 5/20 0.51
MMP7 P09237 5/20 0.51
MMP2 P08253 5/20 0.51
MMP8 P22894 4/20 0.51
F2 P00734 1/20 0.46
PRSS1 P07477 1/20 0.46
PRSS2 P07478 1/20 0.46
PRSS3 P35030 1/20 0.46
TGFBR1 P36897 1/20 0.43
LMNA P02545 1/20 0.43
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23348324 0.91 STS (0.57) STSALDH1A1MMP1MMP9MMP13
SCHEMBL22050819 0.89 STS (0.62) STSALDH1A1MMP1MMP9MMP13
SCHEMBL18397145 0.88 KMT2A (0.51) STSALDH1A1MMP13F2PRSS1
SCHEMBL25220926 0.86 STS (0.53) STSALDH1A1MMP1MMP9MMP13
SCHEMBL17825333 0.84 ALDH1A1 (0.63) ALDH1A1MMP1MMP9MMP13MMP3
SCHEMBL19798266 0.81 ALDH1A1 (0.56) STSALDH1A1MMP1MMP9MMP13
SCHEMBL28481932 0.80 STS (0.52) STSALDH1A1MMP1MMP9MMP13
SCHEMBL25249529 0.80 STS (0.49) STSALDH1A1MMP1MMP9MMP13
SCHEMBL20099653 0.80 KMT2A (0.50) STSALDH1A1MMP13
SCHEMBL2513062 0.79 KMT2A (0.49) STSALDH1A1MMP13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12570650-B2 6-substituted pyridazine compounds as SMARCA2 and/or SMARCA4 degraders AURIGENE ONCOLOGY LIMITED (IN) 2026-03-10 US disclosed
US-20250145609-A1 3-SUBSTITUTED PYRIDAZINE COMPOUNDS AS SMARCA2 AND/OR SMARCA4 DEGRADERS AURIGENE ONCOLOGY LIMITED (IN) 2025-05-08 US disclosed
EP-4476225-A1 3-SUBSTITUTED PYRIDAZINE COMPOUNDS AS SMARCA2 AND/OR SMARCA4 DEGRADERS Aurigene Oncology Limited (IN) 2024-12-18 EP disclosed
CN-114761083-B 5-HT for treating depression 2A Agonists 罗福拉公司 2024-02-13 CN disclosed
US-20240018134-A1 6-Substituted Pyridazine Compounds as SMARCA2 and/or SMARCA4 Degraders AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) 2024-01-18 US disclosed
US-20230365582-A1 NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY ON PROSTAGLANDIN E2 RECEPTOR AND USES THEREOF KANAPH THERAPEUTICS INC. (KR) 2023-11-16 US disclosed
US-20230365582-A1 NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY ON PROSTAGLANDIN E2 RECEPTOR AND USES THEREOF KANAPH THERAPEUTICS INC. (KR) 2023-11-16 US disclosed
US-20230257380-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN (SHANGHAI), INC. (CN) 2023-08-17 US disclosed
US-20230257380-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN (SHANGHAI), INC. (CN) 2023-08-17 US disclosed
WO-2023152666-A1 3-SUBSTITUTED PYRIDAZINE COMPOUNDS AS SMARCA2 AND/OR SMARCA4 DEGRADERS AURIGENE ONCOLOGY LIMITED (IN) 2023-08-17 WO disclosed
US-20180021346-A1 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS LLC 2018-01-25 US disclosed
US-9795613-B2 GLP-1 receptor modulators CELGENE INTERNATIONAL II SÀRL (CH) 2017-10-24 US disclosed
US-9795613-B2 GLP-1 receptor modulators CELGENE INTERNATIONAL II SÀRL (CH) 2017-10-24 US disclosed
US-9795613-B2 GLP-1 receptor modulators CELGENE INTERNATIONAL II SÀRL (CH) 2017-10-24 US disclosed
EP-3230276-A1 GLP-1 RECEPTOR MODULATORS Celgene International II Sarl (CH) 2017-10-18 EP disclosed
US-20160228450-A1 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS LLC 2016-08-11 US disclosed
US-20160228450-A1 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS LLC 2016-08-11 US disclosed
US-20160228450-A1 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS LLC 2016-08-11 US disclosed
WO-2016094729-A1 GLP-1 RECEPTOR MODULATORS CELGENE INTERNATIONAL II SARL (CH) 2016-06-16 WO disclosed
WO-2016094729-A1 GLP-1 RECEPTOR MODULATORS CELGENE INTERNATIONAL II SARL (CH) 2016-06-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160228450-A1 NOVEL GLP-1 RECEPTOR MODULATORS GLP1R, GIPR, NPY1R STS 4832/4885ALDH1A1 4770/4885MMP1 4549/4885
US-20230257380-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE MUSK, ERBB2, NTRK1 STS 3873/4885ALDH1A1 4113/4885MMP1 3772/4885
US-20250145609-A1 3-SUBSTITUTED PYRIDAZINE COMPOUNDS AS SMARCA2 AND/OR SMARCA4 DEGRADERS SMARCC1, SMARCC2, SMARCA4 STS 675/4885ALDH1A1 1991/4885MMP1 2136/4885
US-20230365582-A1 NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY ON PROSTAGLANDIN E2 RECEPTOR AND USES THEREOF PTGER1, PTGIR, PTGDR2 STS 1614/4885ALDH1A1 1126/4885MMP1 796/4885
US-20240018134-A1 6-Substituted Pyridazine Compounds as SMARCA2 and/or SMARCA4 Degraders SMARCC1, SMARCC2, SMARCA4 STS 461/4885ALDH1A1 1495/4885MMP1 2187/4885
US-20180021346-A1 NOVEL GLP-1 RECEPTOR MODULATORS GLP1R, GIPR, NPY1R STS 4832/4885ALDH1A1 4770/4885MMP1 4549/4885
US-12570650-B2 6-substituted pyridazine compounds as SMARCA2 and/or SMARCA4 degraders SMARCC1, SMARCC2, SMARCA1 STS 1615/4885ALDH1A1 1002/4885MMP1 1664/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.