Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 7/20 | 0.42 |
| ▸ | MMP3 | P08254 | 6/20 | 0.42 |
| ▸ | MMP7 | P09237 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 4/20 | 0.40 |
| ▸ | MMP9 | P14780 | 3/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25249529 | 0.88 | STS (0.49) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL29542906 | 0.84 | ALDH1A1 (0.46) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL26349658 | 0.77 | ALDH1A1 (0.54) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL17825333 | 0.77 | ALDH1A1 (0.63) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL23877964 | 0.75 | ALDH1A1 (0.67) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL17785708 | 0.74 | ALDH1A1 (0.71) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL20401085 | 0.72 | ALDH1A1 (0.76) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL30498701 | 0.72 | ALDH1A1 (0.56) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL26103168 | 0.71 | ALDH1A1 (0.65) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL23211919 | 0.70 | ALDH1A1 (0.51) | ALDH1A1F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4208261-A1 | USE OF SOS1 INHIBITORS TO TREAT MALIGNANCIES WITH SHP2 MUTATIONS | Revolution Medicines, Inc. (US) | 2023-07-12 | — | — | EP | disclosed |