SCHEMBL17825591

SCHEMBL17825591

COc1ccc(C(CC(CO)CCNC(=O)C(F)(F)F)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 4/20 0.46
MTNR1A P48039 7/20 0.42
MTNR1B P49286 6/20 0.42
NQO2 P16083 4/20 0.42
CNR1 P21554 2/20 0.41
CNR2 P34972 2/20 0.41
CASR P41180 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24127770 0.85 MTNR1A (0.41) KIF11MTNR1AMTNR1BNQO2CNR1
SCHEMBL17825589 0.85 ATM (0.40) MTNR1AMTNR1BNQO2CNR1CNR2
SCHEMBL17825593 0.82 KDM4E (0.38) MTNR1AMTNR1BCNR1CNR2
SCHEMBL5054255 0.81 KIF11 (0.45) KIF11MTNR1AMTNR1BNQO2
SCHEMBL8843202 0.79 MTNR1A (0.39) KIF11MTNR1AMTNR1BNQO2
SCHEMBL14286735 0.78 NPC1 (0.40) KIF11MTNR1AMTNR1BNQO2
SCHEMBL8842914 0.72 MTNR1A (0.40) KIF11MTNR1AMTNR1BNQO2
SCHEMBL14286694 0.71 NPC1 (0.42) KIF11MTNR1AMTNR1BNQO2
SCHEMBL2686112 0.69 KIF11 (0.64) KIF11
SCHEMBL2898260 0.69 KIF11 (0.60) KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4372091-A2 COMPOSITIONS AND METHODS FOR EDITING NUCLEIC ACIDS IN CELLS UTILIZING OLIGONUCLEOTIDES Woolf, Tod M. (US) 2024-05-22 EP disclosed
EP-3230445-B1 COMPOSITIONS AND METHODS FOR EDITING NUCLEIC ACIDS IN CELLS UTILIZING OLIGONUCLEOTIDES WOOLF TOD M (US) 2024-01-24 EP disclosed
US-20210395729-A1 Compositions and methods for Editing Nucleic Acids in Cells Utilizing Oligonucleotides ETAGEN PHARMA, INC. 2021-12-23 US disclosed
EP-3230445-A2 COMPOSITIONS AND METHODS FOR EDITING NUCLEIC ACIDS IN CELLS UTILIZING OLIGONUCLEOTIDES Woolf, Tod M. (US) 2017-10-18 EP disclosed
WO-2016094845-A2 COMPOSITIONS AND METHODS FOR EDITING NUCLEIC ACIDS IN CELLS UTILIZING OLIGONUCLEOTIDES WOOLF TOD M (US) 2016-06-16 WO disclosed