SCHEMBL17825593

SCHEMBL17825593

COc1cccc(C(CC(CO)CCNC(=O)C(F)(F)F)(c2ccccc2)c2ccccc2)c1OC

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.38
KMT2A Q03164 2/20 0.38
POLB P06746 1/20 0.38
HPGD P15428 2/20 0.36
GAA P10253 1/20 0.36
CNR1 P21554 3/20 0.35
CNR2 P34972 3/20 0.35
ATM Q13315 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
MTNR1A P48039 2/20 0.34
MTNR1B P49286 2/20 0.34
MEN1 O00255 1/20 0.34
PKM P14618 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17825589 0.90 ATM (0.40) KMT2AHPGDGAACNR1CNR2
SCHEMBL6465472 0.84 HPGD (0.38) KDM4EKMT2APOLBHPGDGAA
SCHEMBL17825591 0.82 KIF11 (0.46) CNR1CNR2MTNR1AMTNR1B
SCHEMBL6464526 0.81 HPGD (0.39) KDM4EKMT2APOLBHPGDGAA
SCHEMBL8843206 0.80 HPGD (0.39) KDM4EKMT2APOLBHPGDGAA
SCHEMBL8842917 0.74 HPGD (0.39) KDM4EKMT2APOLBHPGDGAA
SCHEMBL7912706 0.73 KIF11 (0.41) KMT2ASMN1; SMN2MEN1
SCHEMBL8843149 0.71 KMT2A (0.40) KDM4EKMT2APOLBHPGDGAA
SCHEMBL5133757 0.71 NFE2L2 (0.40) KDM4EKMT2AGAAATMSMN1; SMN2
SCHEMBL24127770 0.70 MTNR1A (0.41) CNR1CNR2MTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4372091-A2 COMPOSITIONS AND METHODS FOR EDITING NUCLEIC ACIDS IN CELLS UTILIZING OLIGONUCLEOTIDES Woolf, Tod M. (US) 2024-05-22 EP disclosed
EP-3230445-B1 COMPOSITIONS AND METHODS FOR EDITING NUCLEIC ACIDS IN CELLS UTILIZING OLIGONUCLEOTIDES WOOLF TOD M (US) 2024-01-24 EP disclosed
US-20210395729-A1 Compositions and methods for Editing Nucleic Acids in Cells Utilizing Oligonucleotides ETAGEN PHARMA, INC. 2021-12-23 US disclosed
EP-3230445-A2 COMPOSITIONS AND METHODS FOR EDITING NUCLEIC ACIDS IN CELLS UTILIZING OLIGONUCLEOTIDES Woolf, Tod M. (US) 2017-10-18 EP disclosed
WO-2016094845-A2 COMPOSITIONS AND METHODS FOR EDITING NUCLEIC ACIDS IN CELLS UTILIZING OLIGONUCLEOTIDES WOOLF TOD M (US) 2016-06-16 WO disclosed