Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229468 | 0.89 | SIRT2 (0.78) | SIRT2ALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL17826594 | 0.86 | ALDH1A1 (0.64) | SIRT2ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17826574 | 0.85 | CA1 (0.63) | SIRT2ALDH1A1RAB9ASMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL1707579 | 0.85 | SIRT2 (1.00) | SIRT2 | |
| SCHEMBL17826576 | 0.83 | POLB (0.64) | SIRT2ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17826584 | 0.81 | MEN1 (0.65) | SIRT2ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17826579 | 0.81 | SIRT2 (0.63) | SIRT2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL5448102 | 0.80 | ALDH1A1 (0.68) | SIRT2ALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL17826582 | 0.80 | ALDH1A1 (0.64) | SIRT2ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5455495 | 0.79 | ALDH1A1 (0.72) | SIRT2ALDH1A1NPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365508-B2 | Aroyl thiourea derivatives | UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS (GB) | 2016-06-14 | — | — | US | disclosed |