Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | PPARD | Q03181 | 3/20 | 0.38 |
| ▸ | PPARA | Q07869 | 3/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4975915 | 0.81 | SLC22A6 (0.58) | LMNATSHRNFKB1PMP22FOLH1 | |
| SCHEMBL12048596 | 0.79 | TSHR (0.60) | LMNATSHRNFKB1PMP22FOLH1 | |
| SCHEMBL21128111 | 0.77 | SLC22A6 (0.58) | LMNATSHRNFKB1PMP22FOLH1 | |
| SCHEMBL4978302 | 0.76 | SLC22A6 (0.50) | LMNATSHRNFKB1PMP22FOLH1 | |
| SCHEMBL23051809 | 0.75 | TSHR (0.60) | LMNATSHRNFKB1PMP22PRMT1 | |
| SCHEMBL2209971 | 0.73 | ADRA1A (0.54) | LMNATSHRNFKB1PMP22SLC22A6 | |
| SCHEMBL12967762 | 0.73 | LMNA (0.52) | LMNATSHRNFKB1PMP22FOLH1 | |
| SCHEMBL4977396 | 0.71 | PHF8 (0.57) | LMNATSHRNFKB1PMP22FOLH1 | |
| Adipic Acid SCHEMBL27351012 | 0.69 | LMNA (0.85) | LMNATSHRNFKB1PMP22FOLH1 | |
| Adipic Acid SCHEMBL2244299 | 0.69 | LMNA (1.00) | LMNATSHRNFKB1PMP22FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016094846-A1 | INHIBITORS OF CELLULAR NECROSIS AND RELATED METHODS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-06-16 | — | — | WO | disclosed |