Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.55 |
| ▸ | TNKS | O95271 | 9/20 | 0.55 |
| ▸ | TNKS2 | Q9H2K2 | 9/20 | 0.55 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.48 |
| ▸ | PIM1 | P11309 | 3/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.47 |
| ▸ | GUSB | P08236 | 2/20 | 0.46 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17829771 | 0.90 | TNKS (0.63) | PARP1TNKSTNKS2PARP2PBRM1 | |
| SCHEMBL17829769 | 0.87 | TNKS (0.60) | PARP1TNKSTNKS2PARP2PIM1 | |
| SCHEMBL17829780 | 0.84 | TNKS (0.57) | PARP1TNKSTNKS2PARP2PIM1 | |
| SCHEMBL17829782 | 0.83 | TNKS (0.59) | PARP1TNKSTNKS2PARP2PIM1 | |
| SCHEMBL17829672 | 0.82 | TNKS (0.68) | PARP1TNKSTNKS2PARP2GUSB | |
| SCHEMBL17829728 | 0.82 | TNKS (0.57) | PARP1TNKSTNKS2PARP2PIM1 | |
| SCHEMBL17830142 | 0.81 | TNKS (0.70) | PARP1TNKSTNKS2PARP2GUSB | |
| SCHEMBL17833233 | 0.77 | TNKS (0.56) | PARP1TNKSTNKS2PARP2PTGES | |
| SCHEMBL17829671 | 0.77 | GUSB (0.58) | PARP1TNKSTNKS2PARP2PIM1 | |
| SCHEMBL11086311 | 0.76 | TNKS (0.74) | PARP1TNKSTNKS2PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160168140-A1 | HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS | SYNERECA PHARMACEUTICALS (US) | 2016-06-16 | — | — | US | disclosed |
| US-20160168140-A1 | HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS | SYNERECA PHARMACEUTICALS (US) | 2016-06-16 | — | — | US | disclosed |
| WO-2016094730-A1 | HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS | SYNERECA PHARMACEUTICALS, INC. (US) | 2016-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168140-A1 | HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS | FOS, FOSB, YAP1 | PARP1 2477/4885TNKS 1771/4885TNKS2 2811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.