Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 7/20 | 0.62 |
| ▸ | IDO2 | Q6ZQW0 | 7/20 | 0.62 |
| ▸ | IDO1 | P14902 | 6/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | TOP2A | P11388 | 1/20 | 0.51 |
| ▸ | NCF1 | P14598 | 4/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9103137 | 0.86 | TDO2 (0.62) | TDO2IDO2IDO1LMNANPC1 | |
| SCHEMBL17830821 | 0.78 | TDO2 (0.73) | TDO2IDO2IDO1LMNANPC1 | |
| SCHEMBL9106666 | 0.78 | TDO2 (0.63) | TDO2IDO2IDO1LMNANPC1 | |
| SCHEMBL17830815 | 0.78 | TDO2 (0.63) | TDO2IDO2IDO1TOP2ANCF1 | |
| SCHEMBL17832378 | 0.77 | TDO2 (0.67) | TDO2IDO2IDO1LMNANPC1 | |
| SCHEMBL9101800 | 0.77 | TDO2 (1.00) | TDO2IDO2IDO1LMNANPC1 | |
| Tryptanthrin SCHEMBL29359262 | 0.72 | TDO2 (1.00) | TDO2IDO2IDO1LMNANPC1 | |
| Tryptanthrin SCHEMBL2426211 | 0.72 | TDO2 (1.00) | TDO2IDO2IDO1LMNANPC1 | |
| SCHEMBL26614085 | 0.71 | TDO2 (0.62) | TDO2IDO2IDO1LMNANPC1 | |
| SCHEMBL31382854 | 0.71 | TDO2 (0.62) | TDO2IDO2IDO1LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9630969-B2 | N-alkyl tryptanthrin derivative, preparation method for same, and application thereof | SHANGHAI TIN TSZ BIO VALLEY BIOLOGICAL ENGINEERING CO., LTD (CN) | 2017-04-25 | — | — | US | disclosed |
| US-9630969-B2 | N-alkyl tryptanthrin derivative, preparation method for same, and application thereof | SHANGHAI TIN TSZ BIO VALLEY BIOLOGICAL ENGINEERING CO., LTD (CN) | 2017-04-25 | — | — | US | disclosed |
| US-20160168152-A1 | N-ALKYL TRYPTANTHRIN DERIVATIVE, PREPARATION METHOD FOR SAME, AND APPLICATION THEREOF | SHANGHAI TIN TSZ BIO VALLEY BIOLOGICAL ENGINEERING CO., LTD (CN) | 2016-06-16 | — | — | US | disclosed |
| US-20160168152-A1 | N-ALKYL TRYPTANTHRIN DERIVATIVE, PREPARATION METHOD FOR SAME, AND APPLICATION THEREOF | SHANGHAI TIN TSZ BIO VALLEY BIOLOGICAL ENGINEERING CO., LTD (CN) | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168152-A1 | N-ALKYL TRYPTANTHRIN DERIVATIVE, PREPARATION METHOD FOR SAME, AND APPLICATION THEREOF | IDO1, IDO2, TPH1 | TDO2 9/4885IDO2 2/4885IDO1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.