Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 12/20 | 1.00 |
| ▸ | IDO2 | Q6ZQW0 | 12/20 | 1.00 |
| ▸ | IDO1 | P14902 | 11/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | NPC1 | O15118 | 2/20 | 1.00 |
| ▸ | RAB9A | P51151 | 2/20 | 1.00 |
| ▸ | HTT | P42858 | 2/20 | 1.00 |
| ▸ | NTRK1 | P04629 | 1/20 | 1.00 |
| ▸ | ALOX5 | P09917 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 1/20 | 1.00 |
| ▸ | MAPK8 | P45983 | 1/20 | 1.00 |
| ▸ | NTRK2 | Q16620 | 1/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 1.00 |
| ▸ | APAF1 | O14727 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | MITF | O75030 | 1/20 | 0.70 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptanthrin SCHEMBL2426211 | 1.00 | TDO2 (1.00) | TDO2IDO2IDO1KMT2ALMNA | |
| SCHEMBL9103006 | 0.84 | TDO2 (1.00) | TDO2IDO2IDO1KMT2ALMNA | |
| SCHEMBL9101181 | 0.84 | TDO2 (0.74) | TDO2IDO2IDO1KMT2ALMNA | |
| SCHEMBL30537967 | 0.84 | TDO2 (0.74) | TDO2IDO2IDO1KMT2ALMNA | |
| SCHEMBL9103139 | 0.84 | TDO2 (0.74) | TDO2IDO2IDO1KMT2ALMNA | |
| SCHEMBL12290069 | 0.84 | IDO1 (0.80) | TDO2IDO2IDO1KMT2ALMNA | |
| SCHEMBL19456569 | 0.84 | IDO1 (1.00) | TDO2IDO2IDO1KMT2ALMNA | |
| Benzo[K]Tryptanthrin SCHEMBL9885118 | 0.83 | IDO1 (0.71) | TDO2IDO2IDO1KMT2ALMNA | |
| Benzo[K]Tryptanthrin SCHEMBL30537985 | 0.83 | IDO1 (0.71) | TDO2IDO2IDO1KMT2ALMNA | |
| SCHEMBL9100596 | 0.83 | APAF1 (1.00) | TDO2IDO2IDO1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 467 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4615506-A1 | USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES | Sahin, Fikret (TR) | 2025-09-17 | — | — | EP | claimed |
| US-20250171449-A1 | TRYPTANTHRIN DERIVATIVES WITH THIOSEMICARBAZONE SUBSTITUTION AND USE THEREOF | UNIVERZITA KARLOVA (CZ) | 2025-05-29 | — | — | US | claimed |
| CN-119613411-A | Method for synthesizing coupler aminoketone compound by photocatalysis and application | 贵州大学 | 2025-03-14 | — | — | CN | claimed |
| CN-116655641-B | Tryptamine ketimine compound and derivative thereof, and synthetic method and application thereof | 成都大学 | 2025-03-11 | — | — | CN | claimed |
| CN-119462665-A | 2-Fluoro-3-fatty amine tryptanthrin derivative, preparation method and application thereof | 兴义民族师范学院 | 2025-02-18 | — | — | CN | claimed |
| CN-119462664-A | 1,8 Disubstituted tryptanthrin derivative, preparation method and application thereof | 兴义民族师范学院 | 2025-02-18 | — | — | CN | claimed |
| CN-119285637-A | Tryptanthrin compound, synthesis method and application thereof | 陕西中医药大学 | 2025-01-10 | — | — | CN | claimed |
| EP-4482584-A1 | TRYPTANTHRIN DERIVATIVES WITH THIOSEMICARBAZONE SUBSTITUTION AND USE THEREOF | Univerzita Karlova (CZ) | 2025-01-01 | — | — | EP | claimed |
| WO-2024258363-A1 | USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES | SAHIN FIKRET (TR) | 2024-12-19 | — | — | WO | claimed |
| CN-118766924-A | Application of tryptanthrin in preparation of anti-colon cancer drugs | 陕西中医药大学 | 2024-10-15 | — | — | CN | claimed |
| CN-114874220-A | 8-aminobenzene sulfonamide substituted tryptanthrin derivative and preparation and application thereof | 安徽瀚海博兴生物技术有限公司 | 2022-08-09 | — | — | CN | claimed |
| CN-114874219-A | 2-aminobenzene sulfonamide substituted tryptanthrin derivative and preparation and application thereof | 安徽瀚海博兴生物技术有限公司 | 2022-08-09 | — | — | CN | claimed |
| CN-113009035-B | Method for identifying pharmacodynamic components of traditional Chinese medicine based on knocking out target components and application | 福建卫生职业技术学院 | 2022-08-02 | — | — | CN | claimed |
| WO-2022094174-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ESOPHAGEAL CONDITIONS | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2022-05-05 | — | — | WO | claimed |
| CN-114206312-A | Topical compositions and methods for treating inflammatory skin disorders | 阿佐拉治疗股份有限公司 | 2022-03-18 | — | — | CN | claimed |
| WO-2022053964-A1 | WATER-SOLUBLE TRYPTHANTRIN DERIVATIVES FOR REDOX FLOW BATTERIES | UNIVERSIDADE DE COIMBRA (PT) | 2022-03-17 | — | — | WO | claimed |
| CN-113016814-B | Application of tryptanthrin derivative in treatment of plant virus and germ diseases | 南开大学 | 2022-03-04 | — | — | CN | claimed |
| EP-3955889-A1 | TOPICAL COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY SKIN DISEASES | AZORA THERAPEUTICS, INC. (US) | 2022-02-23 | — | — | EP | claimed |
| CN-113999231-A | Alhaginine A derivative, preparation thereof and application thereof in preventing and treating plant virus and bacterial diseases | 南开大学 | 2022-02-01 | — | — | CN | claimed |
| US-20220023259-A1 | TOPICAL COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY SKIN DISEASES | AZORA THERAPEUTICS, INC. | 2022-01-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250171449-A1 | TRYPTANTHRIN DERIVATIVES WITH THIOSEMICARBAZONE SUBSTITUTION AND USE THEREOF | HTR3C, FTH1, GTF3C3 | TDO2 18/4885IDO2 419/4885IDO1 406/4885 |
| US-20220023259-A1 | TOPICAL COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY SKIN DISEASES | AHR, ARNT, TLR8 | TDO2 38/4885IDO2 22/4885IDO1 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.