Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 9/20 | 0.42 |
| ▸ | BRD4 | O60885 | 7/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.34 |
| ▸ | CTSD | P07339 | 2/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL357257 | 0.82 | — | — | |
| SCHEMBL12160740 | 0.82 | — | — | |
| SCHEMBL20614486 | 0.79 | CREBBP (0.52) | CREBBPBRD4EP300TSHRCRBN | |
| SCHEMBL16316012 | 0.79 | TSHR (0.58) | CREBBPTSHRCRBNBRPF1 | |
| SCHEMBL12809719 | 0.79 | TSHR (0.58) | CREBBPTSHRCRBNBRPF1 | |
| SCHEMBL13074412 | 0.79 | TSHR (0.58) | CREBBPTSHRCRBNBRPF1 | |
| SCHEMBL16350668 | 0.79 | TSHR (0.58) | CREBBPTSHRCRBNBRPF1 | |
| SCHEMBL1226598 | 0.79 | TSHR (0.58) | CREBBPTSHRCRBNBRPF1 | |
| SCHEMBL16316014 | 0.79 | TSHR (0.58) | CREBBPTSHRCRBNBRPF1 | |
| SCHEMBL14005348 | 0.79 | TSHR (0.58) | CREBBPTSHRCRBNBRPF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170107258-A1 | PROTEASE INHIBITION | KING'S COLLEGE LONDON (GB) | 2017-04-20 | — | — | US | disclosed |
| US-9546198-B2 | Cyclic peptides as ADAM protease inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2017-01-17 | — | — | US | disclosed |
| US-20160168202-A1 | Cyclic peptides as ADAM protease inhibitors | KING'S COLLEGE LONDON (GB) | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168202-A1 | Cyclic peptides as ADAM protease inhibitors | ADAM17, ADAM33, ADAM9 | CREBBP 3097/4885BRD4 3177/4885EP300 2849/4885 |
| US-20170107258-A1 | PROTEASE INHIBITION | ADAM17, ADAM33, ADAM8 | CREBBP 3350/4885BRD4 2751/4885EP300 1605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.