SCHEMBL1783131

SCHEMBL1783131

COC(=O)C(C(C)=S)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.52

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 10/20 0.52
SLC6A2 P23975 3/20 0.48
SLC6A4 P31645 3/20 0.48
LMNA P02545 2/20 0.43
ALDH1A1 P00352 1/20 0.43
HTT P42858 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11001290 0.89 SLC6A3 (0.59) SLC6A3SLC6A2SLC6A4LMNAALDH1A1
SCHEMBL14739505 0.82 SLC6A3 (0.50) SLC6A3SLC6A2SLC6A4LMNAALDH1A1
SCHEMBL14739506 0.79 SLC6A3 (0.50) SLC6A3SLC6A2SLC6A4LMNAALDH1A1
SCHEMBL5487986 0.77 SLC6A3 (0.57) SLC6A3SLC6A2SLC6A4LMNAALDH1A1
SCHEMBL1626214 0.77 SLC6A3 (0.57) SLC6A3SLC6A2SLC6A4LMNAALDH1A1
SCHEMBL1566492 0.77 SLC6A3 (0.57) SLC6A3SLC6A2SLC6A4LMNAALDH1A1
SCHEMBL1566494 0.77 SLC6A3 (0.57) SLC6A3SLC6A2SLC6A4LMNAALDH1A1
SCHEMBL9395161 0.76 SLC6A3 (0.56) SLC6A3SLC6A2SLC6A4LMNAALDH1A1
SCHEMBL6988620 0.76 SLC6A3 (0.56) SLC6A3SLC6A2SLC6A4LMNAALDH1A1
SCHEMBL30522901 0.76 SLC6A3 (0.56) SLC6A3SLC6A2SLC6A4LMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2246343-B1 PROCESS FOR PRODUCTION OF THIOPHENE COMPOUND AND INTERMEDIATE THEREOF NISSAN CHEMICAL IND LTD (JP) 2016-05-18 EP disclosed
US-8642786-B2 Process for producing thiophene compound and intermediate thereof NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2014-02-04 US disclosed
US-20140005413-A2 PROCESS FOR PRODUCING THIOPHENE COMPOUND AND INTERMEDIATE THEREOF NISSAN CHEMICAL IND LTD (JP) 2014-01-02 US disclosed
US-20130204013-A1 PROCESS FOR PRODUCING THIOPHENE COMPOUND AND INTERMEDIATE THEREOF NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2013-08-08 US disclosed
US-8420849-B2 Process for producing thiophene compound and intermediate thereof NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2013-04-16 US disclosed
US-8399685-B2 Process for producing thiophene compound and intermediate thereof NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2013-03-19 US disclosed
US-20130060050-A1 PROCESS FOR PRODUCING THIOPHENE COMPOUND AND INTERMEDIATE THEREOF NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2013-03-07 US disclosed
US-20110124884-A1 PROCESS FOR PRODUCING THIOPHENE COMPOUND AND INTERMEDIATE THEREOF NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2011-05-26 US disclosed
EP-2246343-A1 PROCESS FOR PRODUCTION OF THIOPHENE COMPOUND AND INTERMEDIATE THEREOF Nissan Chemical Industries, Ltd. (JP) 2010-11-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130060050-A1 PROCESS FOR PRODUCING THIOPHENE COMPOUND AND INTERMEDIATE THEREOF SULT1E1, CYP3A4, TKT SLC6A3 4010/4885SLC6A2 4760/4885SLC6A4 3166/4885
US-20130204013-A1 PROCESS FOR PRODUCING THIOPHENE COMPOUND AND INTERMEDIATE THEREOF TST, SULT1E1, GRHPR SLC6A3 3041/4885SLC6A2 4474/4885SLC6A4 3021/4885
US-20140005413-A2 PROCESS FOR PRODUCING THIOPHENE COMPOUND AND INTERMEDIATE THEREOF TST, SULT1E1, GRHPR SLC6A3 3041/4885SLC6A2 4474/4885SLC6A4 3021/4885
US-20110124884-A1 PROCESS FOR PRODUCING THIOPHENE COMPOUND AND INTERMEDIATE THEREOF TST, SULT1E1, GRHPR SLC6A3 3041/4885SLC6A2 4474/4885SLC6A4 3021/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.