Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.32 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17490614 | 1.00 | APLNR (0.36) | APLNRSCN9AKAT8POLB | |
| SCHEMBL17835279 | 1.00 | APLNR (0.36) | APLNRSCN9AKAT8POLB | |
| SCHEMBL27375615 | 0.93 | APLNR (0.34) | APLNR | |
| SCHEMBL22144017 | 0.93 | APLNR (0.34) | APLNR | |
| SCHEMBL765004 | 0.86 | — | — | |
| SCHEMBL1962749 | 0.86 | — | — | |
| SCHEMBL21134597 | 0.83 | CYP1A2 (0.35) | APLNRSCN9A | |
| SCHEMBL21779737 | 0.82 | KDM4E (0.37) | POLB | |
| Hydrochloric Acid SCHEMBL28794792 | 0.82 | APLNR (0.36) | APLNRPOLB | |
| SCHEMBL30107026 | 0.79 | APLNR (0.37) | APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100281-A1 | INDOLE AND AZAINDOLES DERIVATIVES AND THEIR USE IN NEURODEGENERATIVE DISEASES | MERCK PATENT GMBH (DE) | 2016-06-23 | — | — | WO | disclosed |
| US-20160168090-A1 | NOVEL INDOLE DERIVATIVES AND THEIR USE IN NEURODEGENERATIVE DISEASES | MERCK PATENT GMBH (DE) | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168090-A1 | NOVEL INDOLE DERIVATIVES AND THEIR USE IN NEURODEGENERATIVE DISEASES | P2RX3, P2RX7, P2RX2 | APLNR 1063/4885SCN9A 1394/4885KAT8 4670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.