Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA3 | P07451 | 2/20 | 0.50 |
| ▸ | CA6 | P23280 | 2/20 | 0.50 |
| ▸ | CA5A | P35218 | 2/20 | 0.50 |
| ▸ | CA7 | P43166 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.50 |
| ▸ | TYR | P14679 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | TPMT | P51580 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL6453701 | 1.00 | TSHR (0.60) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL6231749 | 1.00 | TSHR (0.60) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL20240890 | 1.00 | TSHR (0.60) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL7046508 | 1.00 | TSHR (0.60) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL337710 | 1.00 | TSHR (0.60) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL28803923 | 1.00 | TSHR (0.60) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL20240893 | 0.97 | TSHR (0.63) | TSHRTP53SRD5A2CA1CA2 | |
| Benzoic Acid SCHEMBL2969867 | 0.91 | TSHR (0.64) | TSHRTP53SRD5A2ALDH1A1ALOX15 | |
| Benzoic Acid SCHEMBL164261 | 0.91 | TSHR (0.64) | TSHRTP53SRD5A2ALDH1A1ALOX15 | |
| Terephthalic Acid SCHEMBL23270885 | 0.89 | TP53 (0.61) | TSHRTP53ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112759522-A | High-carbon-chain alkane diamine terephthalate and preparation method and application thereof | 昆山博科化学有限公司 | 2021-05-07 | — | — | CN | disclosed |
| WO-2021083300-A1 | HIGH-CARBON ALKANE DIAMINE TEREPHTHALATE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 昆山博科化学有限公司 | 2021-05-06 | — | — | WO | disclosed |
| US-10982049-B2 | Polyarylene sulfide resin and manufacturing method therefor, poly(arylene sulfonium salt) and manufacturing method therefor, and sulfoxide | DIC CORPORATION (JP) | 2021-04-20 | — | — | US | disclosed |
| CN-112094497-A | Polyaretylenediamine composite material and preparation method thereof | 深圳市中塑新材料有限公司 | 2020-12-18 | — | — | CN | disclosed |
| EP-3042924-B1 | POLYARYLENE SULFIDE RESIN AND MANUFACTURING METHOD THEREFOR, POLY(ARYLENE SULFONIUM SALT) AND MANUFACTURING METHOD THEREFOR, AND SULFOXIDE | DAINIPPON INK & CHEMICALS (JP) | 2020-04-29 | — | — | EP | disclosed |
| EP-3636632-A1 | POLYARYLENE SULFIDE RESIN AND MANUFACTURING METHOD THEREFOR, POLY(ARYLENESULFONIUM SALT) AND MANUFACTURING METHOD THEREFOR, AND SULFOXIDE | DIC Corporation (JP) | 2020-04-15 | — | — | EP | disclosed |
| US-20190300652-A1 | POLYARYLENE SULFIDE RESIN AND MANUFACTURING METHOD THEREFOR, POLY(ARYLENE SULFONIUM SALT) AND MANUFACTURING METHOD THEREFOR, AND SULFOXIDE | DAINIPPON INK & CHEMICALS (JP) | 2019-10-03 | — | — | US | disclosed |
| US-10385168-B2 | Polyarylene sulfide resin and manufacturing method therefor, poly(arylenesulfonium salt) and manufacturing method therefor, and sulfoxide | DIC CORPORATION (JP) | 2019-08-20 | — | — | US | disclosed |
| EP-3034542-B1 | POLYARYLENE SULFIDE RESIN, MANUFACTURING METHOD THEREFOR, AND MOLDING | DAINIPPON INK & CHEMICALS (JP) | 2019-01-30 | — | — | EP | disclosed |
| US-10072124-B2 | Polyarylene sulfide resin, manufacturing method therefor, and molding | DIC CORPORATION (JP) | 2018-09-11 | — | — | US | disclosed |
| US-20170218125-A1 | POLYARYLENE SULFIDE RESIN, MANUFACTURING METHOD THEREFOR, AND MOLDING | DAINIPPON INK & CHEMICALS (JP) | 2017-08-03 | — | — | US | disclosed |
| US-20170218126-A1 | POLYARYLENE SULFIDE RESIN AND MANUFACTURING METHOD THEREFOR, POLY(ARYLENE SULFONIUM SALT) AND MANUFACTURING METHOD THEREFOR, AND SULFOXIDE | DAINIPPON INK & CHEMICALS (JP) | 2017-08-03 | — | — | US | disclosed |
| US-9657142-B2 | Polyarylene sulfide resin and manufacturing method therefor, poly(arylene sulfonium salt) and manufacturing method therefor, and sulfoxide | DIC CORPORATION (JP) | 2017-05-23 | — | — | US | disclosed |
| US-9657141-B2 | Polyarylene sulfide resin, manufacturing method therefor, and molding | DIC CORPORATION (JP) | 2017-05-23 | — | — | US | disclosed |
| US-20160200874-A1 | POLYARYLENE SULFIDE RESIN AND MANUFACTURING METHOD THEREFOR, POLY(ARYLENE SULFONIUM SALT) AND MANUFACTURING METHOD THEREFOR, AND SULFOXIDE | DIC CORPORATION (JP) | 2016-07-14 | — | — | US | disclosed |
| EP-3042924-A1 | POLYARYLENE SULFIDE RESIN AND MANUFACTURING METHOD THEREFOR, POLY(ARYLENE SULFONIUM SALT) AND MANUFACTURING METHOD THEREFOR, AND SULFOXIDE | DIC Corporation (JP) | 2016-07-13 | — | — | EP | disclosed |
| US-20160194450-A1 | POLYARYLENE SULFIDE RESIN, MANUFACTURING METHOD THEREFOR, AND MOLDING | DIC CORPORATION (JP) | 2016-07-07 | — | — | US | disclosed |
| EP-3034542-A1 | POLYARYLENE SULFIDE RESIN, MANUFACTURING METHOD THEREFOR, AND MOLDING | DIC Corporation (JP) | 2016-06-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190300652-A1 | POLYARYLENE SULFIDE RESIN AND MANUFACTURING METHOD THEREFOR, POLY(ARYLENE SULFONIUM SALT) AND MANUFACTURING METHOD THEREFOR, AND SULFOXIDE | GARS1, ASH2L, SULT1A1 | TSHR 3075/4885TP53 3119/4885SRD5A2 715/4885 |
| US-20160200874-A1 | POLYARYLENE SULFIDE RESIN AND MANUFACTURING METHOD THEREFOR, POLY(ARYLENE SULFONIUM SALT) AND MANUFACTURING METHOD THEREFOR, AND SULFOXIDE | GARS1, ASH2L, SULT1A1 | TSHR 3075/4885TP53 3119/4885SRD5A2 715/4885 |
| US-10982049-B2 | Polyarylene sulfide resin and manufacturing method therefor, poly(arylene sulfonium salt) and manufacturing method therefor, and sulfoxide | GARS1, ASH2L, SULT1A1 | TSHR 3075/4885TP53 3119/4885SRD5A2 715/4885 |
| US-20170218126-A1 | POLYARYLENE SULFIDE RESIN AND MANUFACTURING METHOD THEREFOR, POLY(ARYLENE SULFONIUM SALT) AND MANUFACTURING METHOD THEREFOR, AND SULFOXIDE | GARS1, ASH2L, SULT1A1 | TSHR 3075/4885TP53 3119/4885SRD5A2 715/4885 |
| US-10385168-B2 | Polyarylene sulfide resin and manufacturing method therefor, poly(arylenesulfonium salt) and manufacturing method therefor, and sulfoxide | GARS1, ASH2L, SULT1A1 | TSHR 3167/4885TP53 3011/4885SRD5A2 712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.