Sugi Predict

Sugi Predict / Compounds / SCHEMBL17835547

SCHEMBL17835547

SCHEMBL17835547

CC(C)[Si](OC[C@@H](O)c1ccccc1)(C(C)C)C(C)C

nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 3/20 0.48
▸ AOC3 Q16853 5/20 0.43
▸ KDM4E B2RXH2 2/20 0.42
▸ L3MBTL1 Q9Y468 1/20 0.42
▸ RIPK1 Q13546 1/20 0.42
▸ ALDH1A1 P00352 1/20 0.40
▸ IDO1 P14902 1/20 0.39
▸ ADRA2A P08913 1/20 0.38
▸ ADRA2C P18825 1/20 0.38
▸ HIF1A Q16665 1/20 0.38
▸ TSHR P16473 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25419566 1.00 LMNA (0.48) LMNAAOC3KDM4EL3MBTL1RIPK1
SCHEMBL17835608 0.82 RIPK1 (0.47) LMNAAOC3KDM4EL3MBTL1RIPK1
SCHEMBL19666973 0.82 RIPK1 (0.47) LMNAAOC3KDM4EL3MBTL1RIPK1
SCHEMBL26121068 0.82 SMN1; SMN2 (0.45) LMNAKDM4EL3MBTL1IDO1TSHR
SCHEMBL25207293 0.82 SMN1; SMN2 (0.45) LMNAKDM4EL3MBTL1IDO1TSHR
SCHEMBL2424300 0.78 HSD11B1 (0.41) —
SCHEMBL114527 0.77 CYP2C19 (0.45) LMNA
SCHEMBL421878 0.76 CYP2D6 (0.38) LMNAKDM4EALDH1A1ADRA2AADRA2C
SCHEMBL14878508 0.75 RIPK1 (0.47) LMNAAOC3KDM4EL3MBTL1RIPK1
SCHEMBL1154991 0.75 RIPK1 (0.47) LMNAAOC3KDM4EL3MBTL1RIPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12545684-B2 CDK2 inhibitors BLUEPRINT MEDICINES CORPORATION (US) 2026-02-10 — — US disclosed
US-20240383902-A1 CDK2 INHIBITORS BLUEPRINT MEDICINES CORPORATION 2024-11-21 — — US disclosed
US-11970498-B2 CDK2 inhibitors BLUEPRINT MEDICINES CORPORATION (US) 2024-04-30 — — US disclosed
CN-117897384-A CDK2 inhibitors 缆图药品公司 2024-04-16 — — CN disclosed
US-11932648-B2 CDK2 inhibitors BLUEPRINT MEDICINES CORPORATION (US) 2024-03-19 — — US disclosed
US-20230322791-A1 CDK2 INHIBITORS BLUEPRINT MEDICINES CORPORATION 2023-10-12 — — US disclosed
US-20230322791-A1 CDK2 INHIBITORS BLUEPRINT MEDICINES CORPORATION 2023-10-12 — — US disclosed
WO-2023091726-A1 INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) SYROS PHARMACEUTICALS, INC. (US) 2023-05-25 — — WO disclosed
US-20230159535-A1 CDK2 INHIBITORS BLUEPRINT MEDICINES CORPORATION 2023-05-25 — — US disclosed
US-20230159535-A1 CDK2 INHIBITORS BLUEPRINT MEDICINES CORPORATION 2023-05-25 — — US disclosed
US-20190046515-A1 AMIDO THIADIAZOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS GENKYOTEX SA (CH) 2019-02-14 — — US disclosed
US-10130619-B2 Amido thiadiazole derivatives as NADPH oxidase inhibitors GENKYOTEX SUISSE SA (CH) 2018-11-20 — — US disclosed
US-20170348296-A1 AMIDO THIADIAZOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS GENKYOTEX SUISSE SA (CH) 2017-12-07 — — US disclosed
US-20170348296-A1 AMIDO THIADIAZOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS GENKYOTEX SUISSE SA (CH) 2017-12-07 — — US disclosed
US-20170348296-A1 AMIDO THIADIAZOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS GENKYOTEX SUISSE SA (CH) 2017-12-07 — — US disclosed
EP-3233847-A1 AMIDO THIADIAZOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS GenKyoTex Suisse SA (CH) 2017-10-25 — — EP disclosed
WO-2016098005-A1 AMIDO THIADIAZOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS GENKYOTEX SA (CH) 2016-06-23 — — WO disclosed
WO-2016098005-A1 AMIDO THIADIAZOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS GENKYOTEX SA (CH) 2016-06-23 — — WO disclosed
EP-3034500-A1 Amido thiazole derivatives as NADPH oxidase inhibitors GENKYOTEX SA (CH) 2016-06-22 — — EP disclosed
EP-3034500-A1 Amido thiazole derivatives as NADPH oxidase inhibitors GENKYOTEX SA (CH) 2016-06-22 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170348296-A1 AMIDO THIADIAZOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS NOX1, NOX5, CYBB LMNA 4266/4885AOC3 111/4885KDM4E 4240/4885
US-11932648-B2 CDK2 inhibitors CDK2, CDK20, CDK2AP1 LMNA 2403/4885AOC3 4852/4885KDM4E 2160/4885
US-20230322791-A1 CDK2 INHIBITORS CDK2, CDK20, CDK2AP1 LMNA 2403/4885AOC3 4852/4885KDM4E 2160/4885
US-20190046515-A1 AMIDO THIADIAZOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS NOX1, NOX5, CYBB LMNA 4266/4885AOC3 111/4885KDM4E 4240/4885
US-11970498-B2 CDK2 inhibitors CDK2, CDK20, CDK2AP1 LMNA 2403/4885AOC3 4852/4885KDM4E 2160/4885
US-20240383902-A1 CDK2 INHIBITORS CDK2, CDK20, CDK2AP1 LMNA 2403/4885AOC3 4852/4885KDM4E 2160/4885
US-20230159535-A1 CDK2 INHIBITORS CDK2, CDK20, CDK2AP1 LMNA 2403/4885AOC3 4852/4885KDM4E 2160/4885
US-12545684-B2 CDK2 inhibitors CDK2, CDK4, CDK1 LMNA 1435/4885AOC3 3822/4885KDM4E 1727/4885
US-10130619-B2 Amido thiadiazole derivatives as NADPH oxidase inhibitors NOX1, NOX5, CYBB LMNA 4266/4885AOC3 111/4885KDM4E 4240/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.