Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MARK3 | P27448 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5185824 | 0.73 | NPBWR1 (0.43) | PDE9ALMNAHTTSMN1; SMN2MAPKAPK2 | |
| SCHEMBL3551960 | 0.73 | BRD4 (0.39) | SMN1; SMN2MAPKAPK2BRD4POLBXDH | |
| SCHEMBL5186011 | 0.70 | ALDH1A1 (0.48) | LMNAHTTSMN1; SMN2BRD4POLB | |
| SCHEMBL2000128 | 0.64 | HRH3 (0.40) | PDE9AOPRM1OPRD1OPRK1OGFRL1 | |
| SCHEMBL3747115 | 0.62 | MAPKAPK2 (0.66) | LMNAHTTMAPKAPK2POLB | |
| SCHEMBL21033019 | 0.62 | MPI (0.58) | — | |
| SCHEMBL21667330 | 0.62 | ALDH1A1 (0.57) | PDE9AOPRM1OPRD1OPRK1OGFRL1 | |
| SCHEMBL21667310 | 0.61 | ALDH1A1 (0.59) | PDE9AOPRM1OPRD1OPRK1OGFRL1 | |
| SCHEMBL8621565 | 0.61 | MPI (0.57) | SMN1; SMN2 | |
| SCHEMBL11562079 | 0.60 | KMT2A (0.47) | HTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100619-A2 | TREATMENT AND DIAGNOSIS OF CANCER | RGENIX, INC. (US) | 2016-06-23 | — | — | WO | disclosed |