Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 9/20 | 0.45 |
| ▸ | DCPS | Q96C86 | 2/20 | 0.45 |
| ▸ | RBP4 | P02753 | 2/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17837745 | 0.83 | GPR119 (0.55) | AXLKDM4E | |
| SCHEMBL17844410 | 0.80 | AXL (0.48) | AXL | |
| SCHEMBL27734970 | 0.79 | RBP4 (0.47) | RBP4TTRKDM4E | |
| SCHEMBL9748123 | 0.78 | MCHR1 (0.56) | DCPSLTA4HMAPK14MAP4K4 | |
| SCHEMBL17844439 | 0.78 | MAP4K4 (0.48) | AXLDCPSMAP4K4KDM4E | |
| SCHEMBL23365120 | 0.77 | ALDH1A1 (0.52) | RBP4MAPK14KDM4E | |
| SCHEMBL23365193 | 0.77 | HPGD (0.55) | RBP4TTRMAPK14KDM4E | |
| SCHEMBL619980 | 0.77 | DCPS (0.41) | AXLDCPSRBP4 | |
| SCHEMBL5210714 | 0.75 | ALDH1A1 (0.51) | RBP4KDM4E | |
| SCHEMBL3342669 | 0.75 | ABCB1 (0.52) | RBP4MAPK14KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233829-A1 | PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS | Pfizer Inc (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097918-A1 | PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS | PFIZER INC. (US) | 2016-06-23 | — | — | WO | disclosed |