Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17844590 | 1.00 | HMGCR (0.41) | HMGCRHSP90AA1MAPTKDM4EMEN1 | |
| SCHEMBL19680058 | 0.89 | ACHE (0.42) | MAPTKDM4ELMNACYP1A2CYP3A4 | |
| SCHEMBL17844582 | 0.83 | HMGCR (0.54) | HMGCRHSP90AA1MAPTKDM4EMEN1 | |
| SCHEMBL17844481 | 0.75 | STING1 (0.46) | MAPTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL2793251 | 0.74 | GAA (0.58) | HMGCRMAPTKDM4EMEN1NPC1 | |
| SCHEMBL3645035 | 0.72 | HTT (0.72) | HMGCRHSP90AA1MAPTKDM4EMEN1 | |
| SCHEMBL4177645 | 0.72 | HTT (0.52) | HMGCRMAPTKDM4EMEN1NPC1 | |
| SCHEMBL2433323 | 0.71 | USP2 (0.36) | HSP90AA1MEN1KMT2ALMNAMGLL | |
| SCHEMBL2433328 | 0.71 | USP2 (0.36) | HSP90AA1MEN1KMT2ALMNAMGLL | |
| SCHEMBL28167755 | 0.71 | HMGCR (0.75) | HMGCRHSP90AA1MAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107108594-B | Compounds useful as kynurenine monooxygenase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2020-06-09 | — | — | CN | disclosed |
| EP-3233844-B1 | 3-(6-ALKOXY-5-CHLOROBENZO[D]ISOXAZOL-3-YL)PROPANOIC ACID USEFUL AS KYNURENINE MONOOXYGENASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2019-05-15 | — | — | EP | disclosed |
| US-10273232-B2 | 3-(6-alkoxy-5-chlorobenzo[D]isoxazol-3-YL)propanoic acid useful as kynurenine monooxygenase inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-30 | — | — | US | disclosed |
| US-20180170921-A1 | 3-(6-ALKOXY-5-CHLOROBENZO[D]ISOXAZOL-3-YL)PROPANOIC ACID USEFUL AS KYNURENINE MONOOXYGENASE INHIBITORS | DR. FALK PHARMA GMBH (DE) | 2018-06-21 | — | — | US | disclosed |
| US-9932328-B2 | 3-(6-alkoxy-5-chlorobenzo[d]isoxazol-3-yl)propanoic acid useful as kynurenine monooxygenase inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-03 | — | — | US | disclosed |
| US-20170349577-A1 | 3-(6-ALKOXY-5-CHLOROBENZO[D]ISOXAZOL-3-YL)PROPANOIC ACID USEFUL AS KYNURENINE MONOOXYGENASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-12-07 | — | — | US | disclosed |
| EP-3233844-A1 | 3-(6-ALKOXY-5-CHLOROBENZO[D]ISOXAZOL-3-YL)PROPANOIC ACID USEFUL AS KYNURENINE MONOOXYGENASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097144-A1 | 3-(6-ALKOXY-5-CHLOROBENZO[D]ISOXAZOL-3-YL)PROPANOIC ACID USEFUL AS KYNURENINE MONOOXYGENASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180170921-A1 | 3-(6-ALKOXY-5-CHLOROBENZO[D]ISOXAZOL-3-YL)PROPANOIC ACID USEFUL AS KYNURENINE MONOOXYGENASE INHIBITORS | KMO, KYNU, ALOX15 | HMGCR 789/4885HSP90AA1 1914/4885MAPT 676/4885 |
| US-10273232-B2 | 3-(6-alkoxy-5-chlorobenzo[D]isoxazol-3-YL)propanoic acid useful as kynurenine monooxygenase inhibitors | KMO, KYNU, ALOX15 | HMGCR 789/4885HSP90AA1 1914/4885MAPT 676/4885 |
| US-20170349577-A1 | 3-(6-ALKOXY-5-CHLOROBENZO[D]ISOXAZOL-3-YL)PROPANOIC ACID USEFUL AS KYNURENINE MONOOXYGENASE INHIBITORS | KMO, KYNU, ALOX15 | HMGCR 449/4885HSP90AA1 1079/4885MAPT 834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.