Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTPRB | P23467 | 1/20 | 0.42 |
| ▸ | PTPRG | P23470 | 1/20 | 0.42 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17844873 | 0.96 | GRM2 (0.40) | PTPRCPTPN2PTPN1PTPRBPTPRG | |
| SCHEMBL17844847 | 0.84 | CA12 (0.43) | PTPN2PTPN1PTPRBCA12CA1 | |
| SCHEMBL8315125 | 0.78 | SMN1; SMN2 (0.46) | PTPRCPTPN2PTPN1PTPRBPTPRG | |
| SCHEMBL7283510 | 0.74 | FAAH (0.45) | PTPRCPTPN2PTPN1PTPRBPTPRG | |
| SCHEMBL27340806 | 0.74 | POLB (0.44) | PTPRCPTPN2PTPN1PTPRBPTPRG | |
| SCHEMBL9296370 | 0.74 | GRM2 (0.47) | GRM2GRM3POLBLMNASIGMAR1 | |
| SCHEMBL28905900 | 0.73 | POLB (0.43) | PTPRCPTPN2PTPN1PTPRBPTPRG | |
| SCHEMBL7445828 | 0.72 | LTB4R (0.44) | GRM2GRM3POLBLMNASIGMAR1 | |
| SCHEMBL9543962 | 0.72 | SMN1; SMN2 (0.49) | CA12CA1CA7CA14GRM2 | |
| SCHEMBL9544129 | 0.72 | SMN1; SMN2 (0.49) | CA12CA1CA7CA14GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016095088-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |