Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SCD | O00767 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA3 | P07451 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5624626 | 0.81 | PKM (0.56) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11627165 | 0.78 | ALDH1A1 (0.49) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL3391201 | 0.76 | CA12 (0.53) | KDM4EMAPTALDH1A1LMNAHPGD | |
| SCHEMBL12430872 | 0.76 | ALDH1A1 (0.54) | KDM4EMAPTALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL521212 | 0.76 | MAPT (0.97) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL16134481 | 0.74 | GAA (0.63) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL10694441 | 0.74 | KDM4E (0.65) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11140138 | 0.74 | KDM4E (0.47) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7617288 | 0.73 | SMN1; SMN2 (0.74) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL29382304 | 0.73 | SMN1; SMN2 (0.74) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233845-A1 | PARG INHIBITORY COMPOUNDS | Cancer Research Technology Limited (GB) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097749-A1 | PARG INHIBITORY COMPOUNDS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-06-23 | — | — | WO | disclosed |