Sugi Predict

Sugi Predict / Compounds / SCHEMBL521212

SCHEMBL521212

SCHEMBL521212

Nc1ccc2nc(C(F)(F)F)[nH]c2c1

nearest known ligand 0.97

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 11/20 0.97
▸ KDM4E B2RXH2 9/20 0.97
▸ ALDH1A1 P00352 8/20 0.63
▸ HPGD P15428 6/20 0.63
▸ HSD17B10 Q99714 3/20 0.63
▸ CYP1A2 P05177 1/20 0.63
▸ CYP2C9 P11712 1/20 0.63
▸ ALOX15 P16050 1/20 0.63
▸ CYP2C19 P33261 1/20 0.63
▸ SMN1; SMN2 Q16637 7/20 0.58
▸ NPSR1 Q6W5P4 1/20 0.58
▸ MEN1 O00255 9/20 0.54
▸ KMT2A Q03164 9/20 0.54
▸ RXFP1 Q9HBX9 2/20 0.54
▸ CACNA1B Q00975 1/20 0.54
▸ APBA1 Q02410 1/20 0.54
▸ GAA P10253 7/20 0.53
▸ NPC1 O15118 4/20 0.53
▸ RAB9A P51151 4/20 0.53
▸ GLA P06280 3/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16599615 0.86 MAPT (0.73) MAPTKDM4EALDH1A1HPGDHSD17B10
SCHEMBL1131972 0.86 MAPT (0.73) MAPTKDM4EALDH1A1HPGDHSD17B10
Hydrochloric Acid SCHEMBL18062654 0.82 MAPT (0.72) MAPTKDM4EALDH1A1HPGDHSD17B10
SCHEMBL521629 0.82 MAPT (0.68) MAPTKDM4EALDH1A1HPGDHSD17B10
SCHEMBL10694441 0.80 KDM4E (0.65) MAPTKDM4EALDH1A1HPGDHSD17B10
SCHEMBL30016904 0.79 ALDH1A1 (0.63) MAPTKDM4EALDH1A1HPGDHSD17B10
SCHEMBL9866412 0.79 ALDH1A1 (0.63) MAPTKDM4EALDH1A1HPGDHSD17B10
SCHEMBL16042060 0.79 ALDH1A1 (0.63) MAPTKDM4EALDH1A1HPGDHSD17B10
SCHEMBL436153 0.79 ALDH1A1 (0.63) MAPTKDM4EALDH1A1HPGDHSD17B10
SCHEMBL1887466 0.79 ALDH1A1 (0.63) MAPTKDM4EALDH1A1HPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 187 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120156589-A1 ELECTRODE CATALYST FOR FUEL CELL, MANUFACTURING METHOD THEREOF, AND FUEL CELL USING THE SAME SAMSUNG ELECTRONICS CO., LTD. (KR) 2012-06-21 — — US claimed
CN-102123591-A Diaminopyrimidines as plant protection agents BAYER CROPSCIENCE AG 2011-07-13 — — CN claimed
US-20110105472-A1 Diaminopyrimidines as crop protection agents BAYER CROPSCIENCE AG (DE) 2011-05-05 — — US claimed
WO-2010138084-A1 CRYSTAL STRUCTURE OF CAP-FREE HUMAN eIF4E AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2010-12-02 — — WO claimed
US-12606817-B2 Methods of creating and screening DNA-encoded libraries X-CHEM, INC. (US) 2026-04-21 — — US disclosed
US-12378463-B2 Water-based resin with elasticity for applications in cementing and subterranean structures SAUDI ARABIAN OIL COMPANY (SA) 2025-08-05 — — US disclosed
CN-117126578-B Organosilicon polymer/POSS hybrid antifouling coating grafted with antibacterial molecules and preparation method thereof 中国科学院海洋研究所 2025-04-22 — — CN disclosed
CN-116194439-B SOCE inhibitors and therapeutic uses thereof 国家医疗保健研究所 2025-04-08 — — CN disclosed
EP-2247558-B2 NOVEL IMAGING AGENTS FOR DETECTING NEUROLOGICAL DYSFUNCTION LILLY CO ELI (US) 2024-07-03 — — EP disclosed
US-20240116876-A1 SOCE Inhibitors and Therapeutic Uses Thereof Institut National de la Santé et de la Recherche Médicale (FR) 2024-04-11 — — US disclosed
US-20240093081-A1 WATER-BASED RESIN WITH ELASTICITY FOR APPLICATIONS IN CEMENTING AND SUBTERRANEAN STRUCTURES SAUDI ARABIAN OIL COMPANY (SA) 2024-03-21 — — US disclosed
EP-2977406-B1 CURABLE COMPOSITION LG CHEMICAL LTD (KR) 2024-01-24 — — EP disclosed
US-6436982-B1 USEFUL AS ANALGESIC, SEDATIVE OR ANAESTHETIC AGENTS SYNAPTIC PHARMACEUTICAL CORPORATION 2002-08-20 — — US disclosed
US-20020072536-A1 Novel benzimidazole derivatives SYNAPTIC PHARMACEUTICAL CORPORATION 2002-06-13 — — US disclosed
US-6403626-B1 USEFUL AS ANALGESIC, SEDATIVE OR ANAESTHETIC AGENTS SYNAPTIC PHARMACEUTICAL CORPORATION 2002-06-11 — — US disclosed
US-20020065307-A1 Novel benzimidazole derivatives SYNAPTIC PHARMACEUTICAL CORPORATION 2002-05-30 — — US disclosed
US-6316637-B1 SELECTIVE FOR CLONED HUMAN ALPHA 2 RECEPTORS AND ARE USEFUL AS ANALGESIC, SEDATIVE OR ANAESTHETIC AGENTS SYNAPTIC PHARMACEUTICAL CORPORATION 2001-11-13 — — US disclosed
EP-0775134-A4 NOVEL BENZIMIDAZOLE DERIVATIVES SYNAPTIC PHARMA CORP (US) 1997-08-13 — — EP disclosed
EP-0775134-A1 Imidazolin-2-ylaminobenzimidazole derivatives SYNAPTIC PHARMACEUTICAL CORPORATION (US) 1997-05-28 — — EP disclosed
WO-1996004270-A1 NOVEL BENZIMIDAZOLE DERIVATIVES SYNAPTIC PHARMACEUTICAL CORPORATION (US) 1996-02-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240116876-A1 SOCE Inhibitors and Therapeutic Uses Thereof STIM1, ORAI1, STIM2 MAPT 4114/4885KDM4E 1921/4885ALDH1A1 3139/4885
US-20020065307-A1 Novel benzimidazole derivatives OPRD1, OPRL1, OPRM1 MAPT 4094/4885KDM4E 1828/4885ALDH1A1 938/4885
US-20020072536-A1 Novel benzimidazole derivatives OPRD1, OPRL1, OPRM1 MAPT 4095/4885KDM4E 1775/4885ALDH1A1 923/4885
US-12606817-B2 Methods of creating and screening DNA-encoded libraries PCNA, DNA2, POLM MAPT 2409/4885KDM4E 4406/4885ALDH1A1 1889/4885
US-20110105472-A1 Diaminopyrimidines as crop protection agents DDX41, DDX1, DDX5 MAPT 4235/4885KDM4E 2179/4885ALDH1A1 1043/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.