Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | FLT3 | P36888 | 2/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | FLT1 | P17948 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | MARK3 | P27448 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848126 | 0.79 | NTRK1 (0.34) | KDRFLT3PLK4AURKADYRK3 | |
| SCHEMBL17848137 | 0.74 | MAPK1 (0.37) | AURKAPRKD3MAP4K4NTRK1FGFR1 | |
| SCHEMBL17848213 | 0.72 | MKNK2 (0.37) | KDRAURKAROCK2PRKD3MAP4K4 | |
| SCHEMBL17848441 | 0.69 | MAPK1 (0.44) | KDRAURKAPRKD3MAP4K4FGFR1 | |
| SCHEMBL17848254 | 0.66 | ALOX5 (0.31) | — | |
| SCHEMBL17848142 | 0.64 | GSK3B (0.40) | FLT3NTRK1GSK3BDYRK1AMAPK1 | |
| SCHEMBL17848094 | 0.64 | NTRK1 (0.39) | AURKANTRK1GSK3BDYRK1AAURKB | |
| SCHEMBL20560052 | 0.63 | SGK1 (0.39) | KDRFLT3KITNTRK1FLT1 | |
| SCHEMBL17848411 | 0.63 | MPO (0.37) | MAPK1 | |
| SCHEMBL20559532 | 0.62 | JAK2 (0.37) | PLK4AURKADYRK3ROCK2RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233840-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | Eudendron S.r.l. (IT) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016096709-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | EUDENDRON S.R.L. (IT) | 2016-06-23 | — | — | WO | disclosed |