Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848522 | 0.87 | HRH3 (0.59) | KDM4EGAATDP1HRH3ALDH1A1 | |
| SCHEMBL19216371 | 0.78 | TDP1 (0.69) | KDM4EGAATDP1HRH3ALDH1A1 | |
| SCHEMBL17848423 | 0.77 | TSHR (0.66) | KDM4EGAATDP1HRH3ALDH1A1 | |
| SCHEMBL13727157 | 0.75 | PDE2A (0.53) | KDM4EALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL19705247 | 0.74 | HRH3 (0.83) | KDM4EHRH3ALDH1A1LMNA | |
| SCHEMBL17861626 | 0.74 | DRD2 (0.52) | KDM4ETDP1ALDH1A1MEN1KMT2A | |
| SCHEMBL19389876 | 0.73 | KDM4E (0.75) | KDM4EHRH3ALDH1A1LMNA | |
| SCHEMBL17848485 | 0.73 | DRD2 (0.44) | KDM4ETDP1HRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL17842417 | 0.72 | LTA4H (0.52) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL14970552 | 0.72 | HTT (0.64) | KDM4EGAATDP1HRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233077-A1 | DOPAMINE D2 RECEPTOR LIGANDS | The Broad Institute Inc. (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016100940-A1 | DOPAMINE D2 RECEPTOR LIGANDS | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |