Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9467597 | 0.79 | L3MBTL1 (0.42) | HSD17B10ALDH1A1TSHRTDP1CYP2A6 | |
| SCHEMBL5397995 | 0.79 | CYP2A6 (0.39) | HSD17B10ALDH1A1TSHRTDP1CYP2A6 | |
| SCHEMBL455640 | 0.79 | CYP2A6 (0.39) | HSD17B10ALDH1A1TSHRTDP1CYP2A6 | |
| SCHEMBL1262323 | 0.79 | ALDH1A1 (0.39) | HSD17B10ALDH1A1TSHRTDP1CYP2A6 | |
| SCHEMBL8508096 | 0.77 | TDP1 (0.53) | HSD17B10ALDH1A1TDP1CYP1A2CYP2C19 | |
| SCHEMBL808527 | 0.76 | ALDH1A1 (0.40) | HSD17B10ALDH1A1TSHRTDP1CYP2A6 | |
| SCHEMBL1395580 | 0.76 | CALM1 (0.41) | HSD17B10ALDH1A1TSHRTDP1CYP2A6 | |
| SCHEMBL27525101 | 0.76 | KDM4E (0.40) | HSD17B10ALDH1A1TDP1KDM4EGAA | |
| SCHEMBL28039104 | 0.76 | TDP1 (0.40) | HSD17B10ALDH1A1TSHRTDP1CYP1A2 | |
| SCHEMBL2162377 | 0.75 | KDM4E (0.36) | HSD17B10ALDH1A1TSHRTDP1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233078-A1 | USE OF SIGMA RECEPTOR LIGANDS IN OSTEOARTHRITIS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016096125-A1 | USE OF SIGMA RECEPTOR LIGANDS IN OSTEOARTHRITIS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2016-06-23 | — | — | WO | disclosed |