Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 11/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848939 | 0.82 | IRAK4 (0.46) | ALDH1A1LMNAHPGDHSD17B10IRAK4 | |
| SCHEMBL10555200 | 0.79 | ALDH1A1 (0.54) | ALDH1A1LMNAHPGDHSD17B10IRAK4 | |
| SCHEMBL4940332 | 0.79 | IRAK4 (0.56) | ALDH1A1LMNAHPGDHSD17B10IRAK4 | |
| SCHEMBL30579396 | 0.75 | IRAK4 (0.53) | ALDH1A1LMNAHPGDHSD17B10IRAK4 | |
| SCHEMBL10042194 | 0.74 | HTT (0.58) | ALDH1A1LMNAHPGDHSD17B10IRAK4 | |
| SCHEMBL946897 | 0.74 | IRAK4 (0.68) | ALDH1A1IRAK4KDM4ENPC1RAB9A | |
| SCHEMBL309036 | 0.74 | IRAK4 (0.58) | ALDH1A1LMNAHPGDHSD17B10IRAK4 | |
| SCHEMBL9728912 | 0.74 | HSD17B10 (0.52) | ALDH1A1LMNAHPGDHSD17B10IRAK4 | |
| SCHEMBL19997258 | 0.74 | HSD17B10 (0.57) | ALDH1A1LMNAHPGDHSD17B10IRAK4 | |
| SCHEMBL29749543 | 0.73 | LMNA (0.54) | ALDH1A1LMNAHPGDHSD17B10IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233863-A1 | FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS | CMG Pharmaceutical Co., Ltd. (KR) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097869-A1 | FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS | CMG PHARMACEUTICAL CO., LTD. (KR) | 2016-06-23 | — | — | WO | disclosed |