Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 15/20 | 0.49 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 7/20 | 0.46 |
| ▸ | JAK2 | O60674 | 7/20 | 0.46 |
| ▸ | NTRK3 | Q16288 | 6/20 | 0.46 |
| ▸ | INSR | P06213 | 3/20 | 0.46 |
| ▸ | LYN | P07948 | 3/20 | 0.46 |
| ▸ | RET | P07949 | 3/20 | 0.46 |
| ▸ | MET | P08581 | 3/20 | 0.46 |
| ▸ | ROS1 | P08922 | 3/20 | 0.46 |
| ▸ | FGR | P09769 | 3/20 | 0.46 |
| ▸ | KIT | P10721 | 3/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.46 |
| ▸ | TIE1 | P35590 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848931 | 0.84 | NTRK1 (0.45) | NTRK1JAK2NUDT1 | |
| SCHEMBL26968000 | 0.80 | PIK3C3 (0.48) | NTRK1PIK3C3JAK2NTRK3 | |
| SCHEMBL28173612 | 0.80 | PIK3C3 (0.48) | NTRK1PIK3C3JAK2NTRK3 | |
| SCHEMBL27095477 | 0.80 | PIK3C3 (0.48) | NTRK1PIK3C3JAK2NTRK3 | |
| SCHEMBL21097295 | 0.78 | NTRK1 (0.43) | NTRK1PIK3C3 | |
| SCHEMBL28918152 | 0.78 | NTRK1 (0.43) | NTRK1PIK3C3 | |
| SCHEMBL22324907 | 0.76 | ALDH1A1 (0.48) | — | |
| SCHEMBL21760197 | 0.74 | NTRK1 (0.48) | NTRK1PIK3C3NTRK2JAK2NTRK3 | |
| SCHEMBL983254 | 0.73 | NTRK1 (0.48) | NTRK1JAK2 | |
| SCHEMBL988331 | 0.73 | NTRK1 (0.48) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110003214-A | Substituted pyrazolo [1,5-a] pyrimidine compound as TRK kinase inhibitor | 阵列生物制药公司 | 2019-07-12 | — | — | CN | disclosed |
| CN-106008523-B | Substituted pyrazolo [1,5-a] pyrimidine compound as TRK kinase inhibitor | 阵列生物制药公司 | 2019-01-25 | — | — | CN | disclosed |
| CN-106008523-A | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | 阵列生物制药公司 | 2016-10-12 | — | — | CN | disclosed |
| EP-2451812-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2012-05-16 | — | — | EP | disclosed |